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dc.contributor.authorHughes, Katherineen
dc.date.accessioned2020-10-02T23:31:07Z
dc.date.available2020-10-02T23:31:07Z
dc.date.issued2021-06en
dc.identifier.issn1084-9521
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311043
dc.description.abstractSheep, cows, cats, and rabbits are kept by humans for agricultural purposes and as companion animals. Much of the mammary research in these species has focussed on mastitis in the case of ruminants and rabbits, and mammary tumourigenesis in cats and rabbits. However, similarities with the human breast suggest that these species may be currently underutilised as valuable comparative models of breast development and disease. The mammary gland undergoes cyclical postnatal development that will be considered here in the context of these non-traditional model species, with a focus on the mammary microenvironment at different postnatal developmental stages. The second part of this review will consider mammary tumour development. Ruminants are thought to be relatively ‘resistant’ to mammary tumourigenesis, likely due to multiple factors including functional properties of ruminant mammary stem/progenitor cells, diet, and/or the fact that production animals undergo a first parity soon after puberty. By contrast, unneutered female cats and rabbits have a propensity to develop mammary neoplasms, and subsets of these may constitute valuable comparative models of breast cancer.
dc.description.sponsorshipPathological Society of Great Britain and Ireland [grant number ICA 1019 02]; and the British Veterinary Association Animal Welfare Foundation Norman Hayward Fund [grant number NHF_2016_03_KH].
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleComparative mammary gland postnatal development and tumourigenesis in the sheep, cow, cat and rabbit: Exploring the menagerie.en
dc.typeArticle
prism.endingPage195
prism.publicationDate2021en
prism.publicationNameSeminars in cell & developmental biologyen
prism.startingPage186
prism.volume114en
dc.identifier.doi10.17863/CAM.58133
dcterms.dateAccepted2020-09-21en
rioxxterms.versionofrecord10.1016/j.semcdb.2020.09.010en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-06en
dc.contributor.orcidHughes, Katherine [0000-0002-3331-1249]
dc.identifier.eissn1096-3634
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successMon Nov 02 07:30:47 GMT 2020 - Embargo updated*
cam.orpheus.counter4*
rioxxterms.freetoread.startdate2021-10-17


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International