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dc.contributor.authorTong, Allisonen
dc.contributor.authorElliott, Julian Hen
dc.contributor.authorAzevedo, Luciano Cesaren
dc.contributor.authorBaumgart, Amandaen
dc.contributor.authorBersten, Andrewen
dc.contributor.authorCervantes, Liliaen
dc.contributor.authorChew, Derek Pen
dc.contributor.authorCho, Yeoungjeeen
dc.contributor.authorCooper, Tessen
dc.contributor.authorCrowe, Sallyen
dc.contributor.authorDouglas, Ivor Sen
dc.contributor.authorEvangelidis, Nicoleen
dc.contributor.authorFlemyng, Ellaen
dc.contributor.authorHannan, Elyssaen
dc.contributor.authorHorby, Peteren
dc.contributor.authorHowell, Martinen
dc.contributor.authorLee, Jaeheeen
dc.contributor.authorLiu, Emmaen
dc.contributor.authorLorca, Eduardoen
dc.contributor.authorLynch, Deenaen
dc.contributor.authorMarshall, John Cen
dc.contributor.authorGonzalez, Andrea Matusen
dc.contributor.authorMcKenzie, Anneen
dc.contributor.authorManera, Karine Een
dc.contributor.authorMcLeod, Charlieen
dc.contributor.authorMehta, Sangeetaen
dc.contributor.authorMer, Mervynen
dc.contributor.authorMorris, Andrew Conwayen
dc.contributor.authorNseir, Saaden
dc.contributor.authorPovoa, Pedroen
dc.contributor.authorReid, Marken
dc.contributor.authorSakr, Yasseren
dc.contributor.authorShen, Ningen
dc.contributor.authorSmyth, Alan Ren
dc.contributor.authorSnelling, Tomen
dc.contributor.authorStrippoli, Giovanni Fmen
dc.contributor.authorTeixeira-Pinto, Armandoen
dc.contributor.authorTorres, Antonien
dc.contributor.authorTurner, Tarien
dc.contributor.authorViecelli, Andrea Ken
dc.contributor.authorWebb, Steveen
dc.contributor.authorWilliamson, Paula Ren
dc.contributor.authorWoc-Colburn, Lailaen
dc.contributor.authorZhang, Junhuaen
dc.contributor.authorCraig, Jonathan Cen
dc.contributor.authorCOVID-19-Core Outcomes Set (COS) Workshop Investigators,en
dc.date.accessioned2020-10-05T23:31:01Z
dc.date.available2020-10-05T23:31:01Z
dc.date.issued2020-11en
dc.identifier.issn0090-3493
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311099
dc.description.abstractOBJECTIVES: The outcomes reported in trials in coronavirus disease 2019 are extremely heterogeneous and of uncertain patient relevance, limiting their applicability for clinical decision-making. The aim of this workshop was to establish a core outcomes set for trials in people with suspected or confirmed coronavirus disease 2019. DESIGN: Four international online multistakeholder consensus workshops were convened to discuss proposed core outcomes for trials in people with suspected or confirmed coronavirus disease 2019, informed by a survey involving 9,289 respondents from 111 countries. The transcripts were analyzed thematically. The workshop recommendations were used to finalize the core outcomes set. SETTING: International. SUBJECTS: Adults 18 years old and over with confirmed or suspected coronavirus disease 2019, their family members, members of the general public and health professionals (including clinicians, policy makers, regulators, funders, researchers). INTERVENTIONS: None. MEASUREMENTS: None. MAIN RESULTS: Six themes were identified. "Responding to the critical and acute health crisis" reflected the immediate focus on saving lives and preventing life-threatening complications that underpinned the high prioritization of mortality, respiratory failure, and multiple organ failure. "Capturing different settings of care" highlighted the need to minimize the burden on hospitals and to acknowledge outcomes in community settings. "Encompassing the full trajectory and severity of disease" was addressing longer term impacts and the full spectrum of illness (e.g. shortness of breath and recovery). "Distinguishing overlap, correlation and collinearity" meant recognizing that symptoms such as shortness of breath had distinct value and minimizing overlap (e.g. lung function and pneumonia were on the continuum toward respiratory failure). "Recognizing adverse events" refers to the potential harms of new and evolving interventions. "Being cognizant of family and psychosocial wellbeing" reflected the pervasive impacts of coronavirus disease 2019. CONCLUSIONS: Mortality, respiratory failure, multiple organ failure, shortness of breath, and recovery are critically important outcomes to be consistently reported in coronavirus disease 2019 trials.
dc.format.mediumPrinten
dc.languageengen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19-Core Outcomes Set (COS) Workshop Investigatorsen
dc.subjectHumansen
dc.subjectPneumonia, Viralen
dc.subjectCoronavirus Infectionsen
dc.subjectResearch Designen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectHealth Services Accessibilityen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectRandomized Controlled Trials as Topicen
dc.subjectPandemicsen
dc.subjectSymptom Assessmenten
dc.subjectBetacoronavirusen
dc.subjectOutcome Assessment, Health Careen
dc.titleCore Outcomes Set for Trials in People With Coronavirus Disease 2019.en
dc.typeArticle
prism.endingPage1635
prism.issueIdentifier11en
prism.publicationDate2020en
prism.publicationNameCritical care medicineen
prism.startingPage1622
prism.volume48en
dc.identifier.doi10.17863/CAM.58188
dcterms.dateAccepted2020-07-14en
rioxxterms.versionofrecord10.1097/ccm.0000000000004585en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-11en
dc.identifier.eissn1530-0293
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (205214/Z/16/Z)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International