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dc.contributor.authorBarylyuk, Konstantin
dc.contributor.authorKoreny, Ludek
dc.contributor.authorKe, Huiling
dc.contributor.authorButterworth, Simon
dc.contributor.authorCrook, Oliver M
dc.contributor.authorLassadi, Imen
dc.contributor.authorGupta, Vipul
dc.contributor.authorTromer, Eelco
dc.contributor.authorMourier, Tobias
dc.contributor.authorStevens, Tim J
dc.contributor.authorBreckels, Lisa M
dc.contributor.authorPain, Arnab
dc.contributor.authorLilley, Kathryn
dc.contributor.authorWaller, Ross
dc.date.accessioned2020-10-05T23:31:39Z
dc.date.available2020-10-05T23:31:39Z
dc.date.issued2020-11-11
dc.identifier.issn1931-3128
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311121
dc.description.abstractApicomplexan parasites cause major human disease and food insecurity. They owe their considerable success to highly specialized cell compartments and structures. These adaptations drive their recognition, nondestructive penetration, and elaborate reengineering of the host's cells to promote their growth, dissemination, and the countering of host defenses. The evolution of unique apicomplexan cellular compartments is concomitant with vast proteomic novelty. Consequently, half of apicomplexan proteins are unique and uncharacterized. Here, we determine the steady-state subcellular location of thousands of proteins simultaneously within the globally prevalent apicomplexan parasite Toxoplasma gondii. This provides unprecedented comprehensive molecular definition of these unicellular eukaryotes and their specialized compartments, and these data reveal the spatial organizations of protein expression and function, adaptation to hosts, and the underlying evolutionary trajectories of these pathogens.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHumans
dc.subjectApicomplexa
dc.subjectToxoplasma
dc.subjectProteome
dc.subjectProtozoan Proteins
dc.subjectEpitopes
dc.subjectProteomics
dc.subjectHost-Pathogen Interactions
dc.subjectBiological Evolution
dc.titleA Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions.
dc.typeArticle
prism.endingPage766.e9
prism.issueIdentifier5
prism.publicationDate2020
prism.publicationNameCell Host Microbe
prism.startingPage752
prism.volume28
dc.identifier.doi10.17863/CAM.58210
dcterms.dateAccepted2020-09-15
rioxxterms.versionofrecord10.1016/j.chom.2020.09.011
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-11
dc.contributor.orcidBarylyuk, Konstantin [0000-0002-3580-0345]
dc.contributor.orcidTromer, Eelco [0000-0003-3540-7727]
dc.contributor.orcidLilley, Kathryn [0000-0003-0594-6543]
dc.contributor.orcidWaller, Ross [0000-0001-6961-9344]
dc.identifier.eissn1934-6069
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/M011690/1)
pubs.funder-project-idKing Abdullah University of Science and Technology (KAUST) (OCRF-2014-CRG3-2267)
pubs.funder-project-idIsaac Newton Trust (16.08(bc))
pubs.funder-project-idWellcome Trust (214298/Z/18/Z)
pubs.funder-project-idLeverhulme Trust (ECF-2016-562)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/N023129/1)
cam.orpheus.successMon Oct 19 07:30:32 BST 2020 - Embargo updated
cam.orpheus.counter2
rioxxterms.freetoread.startdate2021-10-31


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International