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Distinguishing between Dementia with Lewy Bodies (DLB) and Alzheimer’s Disease (AD) using Mental Health Records: a Classification Approach

Accepted version
Peer-reviewed

Type

Conference Object

Change log

Authors

Wang, Zixu 
Ive, Julia 
Moylett, Sinead 
Mueller, Christoph 
Cardinal, Rudolf N 

Abstract

While Dementia with Lewy Bodies (DLB) is the second most common type of neurodegenerative dementia following Alzheimer’s Disease (AD), it is difficult to distinguish from AD. We propose a method for DLB detection by using mental health record (MHR) documents from a (3-month) period before a patient has been diagnosed with DLB or AD. Our objective is to develop a model that could be clinically useful to differentiate between DLB and AD across datasets from different healthcare institutions. We cast this as a classification task using Convolutional Neural Network (CNN), an efficient neural model for text classification. We experiment with different representation models, and explore the features that contribute to model performances. In addition, we apply temperature scaling, a simple but efficient model calibration method, to produce more reliable predictions. We believe the proposed method has important potential for clinical applications using routine healthcare records, and for generalising to other relevant clinical record datasets. To the best of our knowledge, this is the first attempt to distinguish DLB from AD using mental health records, and to improve the reliability of DLB predictions.

Description

Keywords

3101 Biochemistry and Cell Biology, 4203 Health Services and Systems, 42 Health Sciences, 31 Biological Sciences, 3 Good Health and Well Being

Journal Title

Clinical NLP 2020

Conference Name

3rd Clinical Natural Language Processing Workshop

Journal ISSN

Volume Title

Publisher

Association for Computational Linguistics

Rights

All rights reserved
Sponsorship
Medical Research Council (MC_PC_17213)