ThermoMutDB: a thermodynamic database for missense mutations
Rezende, Pâmela M
Velloso, João PL
Pires, Douglas EV
Nucleic Acids Research
Oxford University Press
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Xavier, J., Nguyen, T., Karmarkar, M., Portelli, S., Rezende, P. M., Velloso, J. P., Ascher, D., & et al. ThermoMutDB: a thermodynamic database for missense mutations. Nucleic Acids Research https://doi.org/10.17863/CAM.58302
Proteins are intricate, dynamic structures, and small changes in their amino acid sequences can lead to large effects on their folding, stability and dynamics. To facilitate the further development and evaluation of methods to predict these changes, we have developed ThermoMutDB, a manually curated database containing more than 14,669 experimental data of thermodynamic parameters for wild type and mutant proteins. This represents an increase of 83% in unique mutations over previous databases and includes thermodynamic information on 204 new proteins. During manual curation we have also corrected annotation errors in previously curated entries. Associated with each entry, we have included information on the unfolding Gibbs free energy and melting temperature change, and have associated entries with available experimental structural information. ThermoMutDB supports users to contribute to new data points and programmatic access to the database via a RESTful API. ThermoMutDB is freely available at: http://biosig.unimelb.edu.au/thermomutdb.
ThermoMutDB, thermodynamic, missense mutations
Newton Fund RCUK-CONFAP Grant awarded by The Medical Research Council (MRC) Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) [MR/M026302/1], Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); the Jack Brockhoff Foundation [JBF 4186, 2016]; Wellcome Trust (200814/Z/16/Z), Investigator Grant from the National Health and Medical Research Council (NHMRC) of Australia [GNT1174405].
Wellcome Trust (093167/Z/10/Z)
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This record's DOI: https://doi.org/10.17863/CAM.58302
This record's URL: https://www.repository.cam.ac.uk/handle/1810/311206
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