Metabolic imaging detects resistance to PI3K alpha inhibition mediated by persistent FOXM1 expression in ER+ breast cancer _ Raw data
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- Main and supplementary raw data. Zip folder with 7 Excel files containing the raw measurements of main FILE 1 figures 1 (1A,!b,1C,1D,1F,1G,1H,1I), FILE 2 figure 2 (2A,2B,2D,2E,2F), FILE 3 figure 3 (3A,3B,3C,3D,3E,3F,3G), FILE 4 figure4 (4A,4B,4C,4D,4E,4F,4G,4H,4I,4J), FILE 5 figure 6 (6A,6B,6C,6D,6E,6H,6I), FILE 6 figure 7 (7B,7C,7D,7E,7F,7G,7H,7I,7J) and FILE 6 supplementary raw data (Supplementary 1A,1C,2A,2C,2D,2E,2F,2G,3A,3C,3D,3E,3F,3G,4A,4B,4C,4E,4G,5D,5E)
- Raw CT and PET data. Zip folder containing the raw DICOM data for the in vivo 18FFDGPET uptake and associated CT experiments.
- Raw MRI data. Zip folder containing the raw DICOM data for the in vivo 1-13C hyperpolarized pyruvate - MRI experiments.
- Raw Western Blot data. Folder containing the original blots pasted on pdf for figures 1, 2, 3, 4 (in 3 docs 4I, 4II, 4III), 6 and 7; and supplementary figures S2,S3,S4 and S5. See the main manuscript for more details (Open access).
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Excel
MATLAB
Vivoquant 3.0 software
Keywords
raw data, imaging, biomarker, FOXM1, PI3K alpha inhibitor, breast cancer, resistance, early detection, MRI
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Cancer Research Uk (None)
Cancer Research UK (CB4100)
Cancer Research UK (CB4100)
This work was supported by a CRUK Programme grant (A28289) and by the CRUK-EPSRC Imaging Centre in Cambridge and Manchester (16465) and by NIH grants P30 CA008748 and R01CA190642-01, the Breast Cancer Research Foundation and by grants from Stand Up to Cancer (Cancer Drug Combination Convergence Team), the V Foundation and the National Science Foundation.