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dc.contributor.authorIbata, Neilen
dc.contributor.authorTerentjev, Eugeneen
dc.date.accessioned2020-10-08T14:58:28Z
dc.date.available2020-10-08T14:58:28Z
dc.date.issued2020-11en
dc.identifier.issn0006-3495
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311247
dc.description.abstractThe eukaryotic cell develops organelles in order to sense and respond to the mechanical properties of its surroundings. These mechanosensing organelles aggregate into symmetry-breaking patterns to mediate cell motion and differentiation on substrate. The spreading of a cell plated onto a substrate is one of the simplest paradigms in which angular symmetry-breaking assemblies of mechanical sensors are seen to develop. We review evidence for the importance of the edge of the cell-extracelullar matrix adhesion area in the aggregation of mechanosensors, and develop a theoretical model of mechanosensors clustering into nascent focal adhesions on this contact ring. To study the spatial patterns arising on this topological feature, we use a 1D lattice model with the nearest-neighbor interaction between individual integrin-mediated mechanosensors.} We find the effective Ginzburg-Landau free energy for this model, and determine the spectrum of spatial modes as the cell spreads and increases its contact area with the substrate. To test our model, we compare its predictions with measured distributions of paxillin in spreading fibroblasts.
dc.description.sponsorshipBBRSC DTP Cambridge (grant no. EP/M508007/1
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherBiophysical Society
dc.rightsAll rights reserved
dc.subjectCell-Matrix Junctionsen
dc.subjectFocal Adhesionsen
dc.subjectExtracellular Matrixen
dc.subjectIntegrinsen
dc.subjectCell Adhesionen
dc.subjectPaxillinen
dc.titleDevelopment of Nascent Focal Adhesions in Spreading Cells.en
dc.typeArticle
prism.endingPage2073
prism.issueIdentifier10en
prism.publicationDate2020en
prism.publicationNameBiophysical journalen
prism.startingPage2063
prism.volume119en
dc.identifier.doi10.17863/CAM.58338
dcterms.dateAccepted2020-09-21en
rioxxterms.versionofrecord10.1016/j.bpj.2020.09.037en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-11en
dc.contributor.orcidTerentjev, Eugene [0000-0003-3517-6578]
dc.identifier.eissn1542-0086
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successMon Nov 09 07:30:54 GMT 2020 - Embargo updated*
cam.orpheus.counter5*
rioxxterms.freetoread.startdate2021-10-15


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