A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.
Description
Keywords
Journal Title
Conference Name
Journal ISSN
1540-9538
Volume Title
Publisher
Publisher DOI
Sponsorship
Medical Research Council (G0802051)
Medical Research Council (G0400192)
British Heart Foundation (None)
Medical Research Council (MC_UU_12012/2)
Medical Research Council (MC_UU_12012/5)
MRC (MC_UU_00014/2)
MRC (MC_UU_00014/5)
British Heart Foundation (RG/18/7/33636)
Medical Research Council (MC_PC_12012)
Medical Research Council (G0600717/1)