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dc.contributor.authorAzizi, Alexander A.
dc.contributor.authorHadjinicolaou, Andreas V.
dc.contributor.authorGoncalves, Carla
dc.contributor.authorDuckworth, Adam
dc.contributor.authorBasu, Bristi
dc.date.accessioned2020-10-09T13:12:30Z
dc.date.available2020-10-09T13:12:30Z
dc.date.issued2020-09-25
dc.date.submitted2020-06-09
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311289
dc.description.abstractCombined hepatocellular-cholangiocarcinoma (cHCC-ICC) is an uncommon and aggressive form of primary liver cancer. Currently, there are no international guidelines for optimal management. For localized tumors, radical resection represents the preferred treatment option, whereas for advanced tumors, systemic therapies recommended for intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are often selected. Emerging information from comparative cohort studies, genomic and transcriptomic data sets are starting to build a case for rationalized approaches to systemic treatment in the advanced setting specific to cHCC-ICC.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectOncology
dc.subjectCombined hepatocellular-cholangiocarcinoma
dc.subjectcHCC-ICC
dc.subjectcHCC-CCA
dc.subjectbiphenotypic
dc.subjectprimary liver cancer
dc.subjectgenomics
dc.subjectsystemic therapy
dc.titleUpdate on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma
dc.typeArticle
dc.date.updated2020-10-09T13:12:30Z
prism.publicationNameFrontiers in Oncology
prism.volume10
dc.identifier.doi10.17863/CAM.58383
dcterms.dateAccepted2020-08-26
rioxxterms.versionofrecord10.3389/fonc.2020.570958
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2234-943X


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)