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dc.contributor.authorScheffer, Louis K
dc.contributor.authorXu, C Shan
dc.contributor.authorJanuszewski, Michal
dc.contributor.authorLu, Zhiyuan
dc.contributor.authorTakemura, Shin-ya
dc.contributor.authorHayworth, Kenneth J
dc.contributor.authorHuang, Gary B
dc.contributor.authorShinomiya, Kazunori
dc.contributor.authorMaitlin-Shepard, Jeremy
dc.contributor.authorBerg, Stuart
dc.contributor.authorClements, Jody
dc.contributor.authorHubbard, Philip M
dc.contributor.authorKatz, William T
dc.contributor.authorUmayam, Lowell
dc.contributor.authorZhao, Ting
dc.contributor.authorAckerman, David
dc.contributor.authorBlakely, Tim
dc.contributor.authorBogovic, John
dc.contributor.authorDolafi, Tom
dc.contributor.authorKainmueller, Dagmar
dc.contributor.authorKawase, Takashi
dc.contributor.authorKhairy, Khaled A
dc.contributor.authorLeavitt, Laramie
dc.contributor.authorLi, Peter H
dc.contributor.authorLindsey, Larry
dc.contributor.authorNeubarth, Nicole
dc.contributor.authorOlbris, Donald J
dc.contributor.authorOtsuna, Hideo
dc.contributor.authorTrautman, Eric T
dc.contributor.authorIto, Masayoshi
dc.contributor.authorBates, Alexander S
dc.contributor.authorGoldammer, Jens
dc.contributor.authorWolff, Tanya
dc.contributor.authorSvirskas, Robert
dc.contributor.authorSchlegel, Philipp
dc.contributor.authorNeace, Erika
dc.contributor.authorKnecht, Christopher J
dc.contributor.authorAlvarado, Chelsea X
dc.contributor.authorBailey, Dennis A
dc.contributor.authorBallinger, Samantha
dc.contributor.authorBorycz, Jolanta A
dc.contributor.authorCanino, Brandon S
dc.contributor.authorCheatham, Natasha
dc.contributor.authorCook, Michael
dc.contributor.authorDreher, Marisa
dc.contributor.authorDuclos, Octave
dc.contributor.authorEubanks, Bryon
dc.contributor.authorFairbanks, Kelli
dc.contributor.authorFinley, Samantha
dc.contributor.authorForknall, Nora
dc.contributor.authorFrancis, Audrey
dc.contributor.authorHopkins, Gary Patrick
dc.contributor.authorJoyce, Emily M
dc.contributor.authorKim, SungJin
dc.contributor.authorKirk, Nicole A
dc.contributor.authorKovalyak, Julie
dc.contributor.authorLauchie, Shirley A
dc.contributor.authorLohff, Alanna
dc.contributor.authorMaldonado, Charli
dc.contributor.authorManley, Emily A
dc.contributor.authorMcLin, Sari
dc.contributor.authorMooney, Caroline
dc.contributor.authorNdama, Miatta
dc.contributor.authorOgundeyi, Omotara
dc.contributor.authorOkeoma, Nneoma
dc.contributor.authorOrdish, Christopher
dc.contributor.authorPadilla, Nicholas
dc.contributor.authorPatrick, Christopher M
dc.contributor.authorPaterson, Tyler
dc.contributor.authorPhillips, Elliott E
dc.contributor.authorPhillips, Emily M
dc.contributor.authorRampally, Neha
dc.contributor.authorRibeiro, Caitlin
dc.contributor.authorRobertson, Madelaine K
dc.contributor.authorRymer, Jon Thomson
dc.contributor.authorRyan, Sean M
dc.contributor.authorSammons, Megan
dc.contributor.authorScott, Anne K
dc.contributor.authorScott, Ashley L
dc.contributor.authorShinomiya, Aya
dc.contributor.authorSmith, Claire
dc.contributor.authorSmith, Kelsey
dc.contributor.authorSmith, Natalie L
dc.contributor.authorSobeski, Margaret A
dc.contributor.authorSuleiman, Alia
dc.contributor.authorSwift, Jackie
dc.contributor.authorTakemura, Satoko
dc.contributor.authorTalebi, Iris
dc.contributor.authorTarnogorska, Dorota
dc.contributor.authorTenshaw, Emily
dc.contributor.authorTokhi, Temour
dc.contributor.authorWalsh, John J
dc.contributor.authorYang, Tansy
dc.contributor.authorHorne, Jane Anne
dc.contributor.authorLi, Feng
dc.contributor.authorParekh, Ruchi
dc.contributor.authorRivlin, Patricia K
dc.contributor.authorJayaraman, Vivek
dc.contributor.authorCosta, Marta
dc.contributor.authorJefferis, Gregory SXE
dc.contributor.authorIto, Kei
dc.contributor.authorSaalfeld, Stephan
dc.contributor.authorGeorge, Reed
dc.contributor.authorMeinertzhagen, Ian A
dc.contributor.authorRubin, Gerald M
dc.contributor.authorHess, Harald F
dc.contributor.authorJain, Viren
dc.contributor.authorPlaza, Stephen M
dc.date.accessioned2020-10-10T05:06:35Z
dc.date.available2020-10-10T05:06:35Z
dc.date.issued2020-09-07
dc.date.submitted2020-03-31
dc.identifier.other57443
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311341
dc.description.abstractThe neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain.
dc.languageen
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectComputational and Systems Biology
dc.subjectNeuroscience
dc.subjectconnectome
dc.subjectbrain regions
dc.subjectcell types
dc.subjectgraph properties
dc.subjectconnectome reconstuction methods
dc.subjectsynapse detecton
dc.subjectD. melanogaster
dc.titleA connectome and analysis of the adult Drosophila central brain
dc.typeArticle
dc.date.updated2020-10-10T05:06:34Z
prism.publicationNameeLife
prism.volume9
dc.identifier.doi10.17863/CAM.58431
dcterms.dateAccepted2020-09-01
rioxxterms.versionofrecord10.7554/elife.57443
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Marder, Eve
datacite.contributor.supervisorsenior_editor: Eisen, Michael B
dc.contributor.orcidScheffer, Louis K [0000-0002-3289-6564]
dc.contributor.orcidXu, C Shan [0000-0002-8564-7836]
dc.contributor.orcidJanuszewski, Michal [0000-0002-3480-2744]
dc.contributor.orcidLu, Zhiyuan [0000-0002-4128-9774]
dc.contributor.orcidTakemura, Shin-ya [0000-0003-2400-6426]
dc.contributor.orcidHuang, Gary B [0000-0002-9606-3510]
dc.contributor.orcidShinomiya, Kazunori [0000-0003-0262-6421]
dc.contributor.orcidMaitlin-Shepard, Jeremy [0000-0001-8453-7961]
dc.contributor.orcidHubbard, Philip M [0000-0002-6746-5035]
dc.contributor.orcidKatz, William T [0000-0002-9417-6212]
dc.contributor.orcidAckerman, David [0000-0003-0172-6594]
dc.contributor.orcidBlakely, Tim [0000-0003-0995-5471]
dc.contributor.orcidBogovic, John [0000-0002-4829-9457]
dc.contributor.orcidKainmueller, Dagmar [0000-0002-9830-2415]
dc.contributor.orcidKhairy, Khaled A [0000-0002-9274-5928]
dc.contributor.orcidLi, Peter H [0000-0001-6193-4454]
dc.contributor.orcidTrautman, Eric T [0000-0001-8588-0569]
dc.contributor.orcidBates, Alexander S [0000-0002-1195-0445]
dc.contributor.orcidGoldammer, Jens [0000-0002-5623-8339]
dc.contributor.orcidWolff, Tanya [0000-0002-8681-1749]
dc.contributor.orcidSvirskas, Robert [0000-0001-8374-6008]
dc.contributor.orcidSchlegel, Philipp [0000-0002-5633-1314]
dc.contributor.orcidKnecht, Christopher J [0000-0002-5663-5967]
dc.contributor.orcidAlvarado, Chelsea X [0000-0002-5973-7512]
dc.contributor.orcidBailey, Dennis A [0000-0002-4675-8373]
dc.contributor.orcidBorycz, Jolanta A [0000-0002-4402-9230]
dc.contributor.orcidCanino, Brandon S [0000-0002-8454-865X]
dc.contributor.orcidCook, Michael [0000-0002-7892-6845]
dc.contributor.orcidDreher, Marisa [0000-0002-0041-9229]
dc.contributor.orcidEubanks, Bryon [0000-0002-9288-2009]
dc.contributor.orcidFairbanks, Kelli [0000-0002-6601-4830]
dc.contributor.orcidFinley, Samantha [0000-0002-8086-206X]
dc.contributor.orcidForknall, Nora [0000-0003-2139-7599]
dc.contributor.orcidFrancis, Audrey [0000-0003-1974-7174]
dc.contributor.orcidJoyce, Emily M [0000-0001-5794-6321]
dc.contributor.orcidKovalyak, Julie [0000-0001-7864-7734]
dc.contributor.orcidLauchie, Shirley A [0000-0001-8223-9522]
dc.contributor.orcidLohff, Alanna [0000-0002-1242-1836]
dc.contributor.orcidMcLin, Sari [0000-0002-9120-1136]
dc.contributor.orcidPatrick, Christopher M [0000-0001-8830-1892]
dc.contributor.orcidPhillips, Elliott E [0000-0002-4918-2058]
dc.contributor.orcidPhillips, Emily M [0000-0001-7615-301X]
dc.contributor.orcidRobertson, Madelaine K [0000-0002-1764-0245]
dc.contributor.orcidRymer, Jon Thomson [0000-0002-4271-6774]
dc.contributor.orcidRyan, Sean M [0000-0002-8879-6108]
dc.contributor.orcidSammons, Megan [0000-0003-4516-5928]
dc.contributor.orcidShinomiya, Aya [0000-0002-6358-9567]
dc.contributor.orcidSmith, Natalie L [0000-0002-8271-9873]
dc.contributor.orcidSwift, Jackie [0000-0003-1321-8183]
dc.contributor.orcidTakemura, Satoko [0000-0002-2863-0050]
dc.contributor.orcidTalebi, Iris [0000-0002-0173-8053]
dc.contributor.orcidTarnogorska, Dorota [0000-0002-7063-6165]
dc.contributor.orcidWalsh, John J [0000-0002-7176-4708]
dc.contributor.orcidYang, Tansy [0000-0003-1131-0410]
dc.contributor.orcidHorne, Jane Anne [0000-0001-9673-2692]
dc.contributor.orcidParekh, Ruchi [0000-0002-8060-2807]
dc.contributor.orcidJayaraman, Vivek [0000-0003-3680-7378]
dc.contributor.orcidCosta, Marta [0000-0001-5948-3092]
dc.contributor.orcidJefferis, Gregory SXE [0000-0002-0587-9355]
dc.contributor.orcidIto, Kei [0000-0002-7274-5533]
dc.contributor.orcidSaalfeld, Stephan [0000-0002-4106-1761]
dc.contributor.orcidRubin, Gerald M [0000-0001-8762-8703]
dc.contributor.orcidHess, Harald F [0000-0003-3000-1533]
dc.contributor.orcidPlaza, Stephen M [0000-0001-7425-8555]
dc.identifier.eissn2050-084X
pubs.funder-project-idHoward Hughes Medical Institute (Internal funding)
pubs.funder-project-idGoogle (Internal funding)
pubs.funder-project-idWellcome (203261/Z/16/Z)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)