Show simple item record

dc.contributor.authorJones, Andrew JYen
dc.contributor.authorGabriel, Florianen
dc.contributor.authorTandale, Aditien
dc.contributor.authorNietlispach, Danielen
dc.date.accessioned2020-10-14T23:31:42Z
dc.date.available2020-10-14T23:31:42Z
dc.date.issued2020-10-15en
dc.identifier.issn1420-3049
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311535
dc.description.abstractOver the past decade the vast amount of information generated through structural and biophysical studies of GPCRs has provided unprecedented mechanistic insight into the complex signalling behaviour of these receptors. With this recent information surge it has also become increasingly apparent that in order to reproduce the various effects that lipids and membranes exert on the biological function for these allosteric receptors, in vitro studies of GPCRs need to be conducted under conditions that adequately approximate the native lipid bilayer environment. In the first part of this review we assess some of the more general effects that a membrane environment exerts on lipid bilayer-embedded proteins such as GPCRs. This is then followed by the consideration of more specific effects, including stoichiometric interactions with specific lipid subtypes. In the final section we survey a range of different membrane mimetics that are currently used for in vitro studies, with a focus on NMR applications.
dc.description.sponsorshipThis work was supported by the Biotechnology and Biological Sciences Research Council (BB/S015892/1) (DN & AJYJ), German Academic Exchange Service (FG), Newnham College and a Trinity Henry-Barlow Scholarship (AT).
dc.format.mediumElectronicen
dc.languageengen
dc.publisherMDPI AG
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectHumansen
dc.subjectMembrane Lipidsen
dc.subjectLipid Bilayersen
dc.subjectReceptors, G-Protein-Coupleden
dc.subjectMagnetic Resonance Spectroscopyen
dc.subjectBiomimeticsen
dc.subjectSignal Transductionen
dc.subjectMolecular Structureen
dc.subjectPhysical Phenomenaen
dc.titleStructure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches.en
dc.typeArticle
prism.issueIdentifier20en
prism.publicationDate2020en
prism.publicationNameMolecules (Basel, Switzerland)en
prism.volume25en
dc.identifier.doi10.17863/CAM.58628
dcterms.dateAccepted2020-10-12en
rioxxterms.versionofrecord10.3390/molecules25204729en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2020-10-15en
dc.contributor.orcidNietlispach, Daniel [0000-0003-4364-9291]
dc.identifier.eissn1420-3049
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/S015892/1)
cam.orpheus.counter2*
rioxxterms.freetoread.startdate2023-10-14


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record