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dc.contributor.authorPashayan, Nora
dc.contributor.authorAntoniou, Antonis C.
dc.contributor.authorIvanus, Urska
dc.contributor.authorEsserman, Laura J.
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorFrench, David
dc.contributor.authorSroczynski, Gaby
dc.contributor.authorHall, Per
dc.contributor.authorCuzick, Jack
dc.contributor.authorEvans, D. Gareth
dc.contributor.authorSimard, Jacques
dc.contributor.authorGarcia-Closas, Montserrat
dc.contributor.authorSchmutzler, Rita
dc.contributor.authorWegwarth, Odette
dc.contributor.authorPharoah, Paul
dc.contributor.authorMoorthie, Sowmiya
dc.contributor.authorDe Montgolfier, Sandrine
dc.contributor.authorBaron, Camille
dc.contributor.authorHerceg, Zdenko
dc.contributor.authorTurnbull, Clare
dc.contributor.authorBalleyguier, Corinne
dc.contributor.authorRossi, Paolo Giorgi
dc.contributor.authorWesseling, Jelle
dc.contributor.authorRitchie, David
dc.contributor.authorTischkowitz, Marc
dc.contributor.authorBroeders, Mireille
dc.contributor.authorReisel, Dan
dc.contributor.authorMetspalu, Andres
dc.contributor.authorCallender, Thomas
dc.contributor.authorde Koning, Harry
dc.contributor.authorDevilee, Peter
dc.contributor.authorDelaloge, Suzette
dc.contributor.authorSchmidt, Marjanka K.
dc.contributor.authorWidschwendter, Martin
dc.date.accessioned2020-10-17T15:11:14Z
dc.date.available2020-10-17T15:11:14Z
dc.date.issued2020-06-18
dc.identifier.issn1759-4774
dc.identifier.others41571-020-0388-9
dc.identifier.other388
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311641
dc.description.abstractAbstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early detection and prevention of breast cancer. In a consensus conference held in 2019, the members of this network identified research areas requiring development to enable evidence-based personalized interventions that might improve the benefits and reduce the harms of existing breast cancer screening and prevention programmes. The priority areas identified were: 1) breast cancer subtype-specific risk assessment tools applicable to women of all ancestries; 2) intermediate surrogate markers of response to preventive measures; 3) novel non-surgical preventive measures to reduce the incidence of breast cancer of poor prognosis; and 4) hybrid effectiveness–implementation research combined with modelling studies to evaluate the long-term population outcomes of risk-based early detection strategies. The implementation of such programmes would require health-care systems to be open to learning and adapting, the engagement of a diverse range of stakeholders and tailoring to societal norms and values, while also addressing the ethical and legal issues. In this Consensus Statement, we discuss the current state of breast cancer risk prediction, risk-stratified prevention and early detection strategies, and their implementation. Throughout, we highlight priorities for advancing each of these areas.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectConsensus Statement
dc.subject/692/699/67/1347
dc.subject/692/4028/67/2195
dc.subject/692/4028/67/2322
dc.subjectconsensus-statement
dc.titlePersonalized early detection and prevention of breast cancer: ENVISION consensus statement
dc.typeArticle
dc.date.updated2020-10-17T15:11:13Z
prism.endingPage705
prism.issueIdentifier11
prism.publicationNameNature Reviews Clinical Oncology
prism.startingPage687
prism.volume17
dc.identifier.doi10.17863/CAM.58732
dcterms.dateAccepted2020-05-06
rioxxterms.versionofrecord10.1038/s41571-020-0388-9
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidPashayan, Nora [0000-0003-0843-2468]
dc.contributor.orcidIvanus, Urska [0000-0002-7909-522X]
dc.contributor.orcidEaston, Douglas F. [0000-0003-2444-3247]
dc.contributor.orcidFrench, David [0000-0002-7663-7804]
dc.contributor.orcidSimard, Jacques [0000-0001-6906-3390]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidDe Montgolfier, Sandrine [0000-0002-4216-9379]
dc.contributor.orcidHerceg, Zdenko [0000-0003-4109-3154]
dc.contributor.orcidRitchie, David [0000-0003-4816-113X]
dc.contributor.orcidMetspalu, Andres [0000-0002-3718-796X]
dc.contributor.orcidCallender, Thomas [0000-0001-8440-9433]
dc.contributor.orcidde Koning, Harry [0000-0003-4682-3646]
dc.contributor.orcidDelaloge, Suzette [0000-0003-2106-9165]
dc.contributor.orcidSchmidt, Marjanka K. [0000-0002-2228-429X]
dc.contributor.orcidWidschwendter, Martin [0000-0002-7778-8380]
dc.identifier.eissn1759-4782


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