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dc.contributor.authorFalk, Martin Jen
dc.contributor.authorDuwel, Amyen
dc.contributor.authorColwell, Lucyen
dc.contributor.authorBrenner, Michael Pen
dc.date.accessioned2020-10-19T23:31:12Z
dc.date.available2020-10-19T23:31:12Z
dc.date.issued2019-12en
dc.identifier.issn0031-9007
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311693
dc.description.abstractCollagen consists of three peptides twisted together through a periodic array of hydrogen bonds. Here we use this as inspiration to find design rules for programmed specific interactions for self-assembling synthetic collagenlike triple helices, starting from disordered configurations. The assembly generically nucleates defects in the triple helix, the characteristics of which can be manipulated by spatially varying the enthalpy of helix formation. Defect formation slows assembly, evoking kinetic pathologies that have been observed to mutations in the primary collagen amino acid sequence. The controlled formation and interaction between defects gives a route for hierarchical self-assembly of bundles of twisted filaments.
dc.format.mediumPrinten
dc.languageengen
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectCollagenen
dc.subjectPeptidesen
dc.subjectAmino Acid Sequenceen
dc.subjectModels, Chemicalen
dc.subjectModels, Molecularen
dc.subjectNanostructuresen
dc.subjectProtein Conformation, alpha-Helicalen
dc.titleCollagen-Inspired Self-Assembly of Twisted Filaments.en
dc.typeArticle
prism.issueIdentifier23en
prism.publicationDate2019en
prism.publicationNamePhysical review lettersen
prism.startingPage238102
prism.volume123en
dc.identifier.doi10.17863/CAM.58783
dcterms.dateAccepted2019-11-01en
rioxxterms.versionofrecord10.1103/physrevlett.123.238102en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-12en
dc.contributor.orcidColwell, Lucy [0000-0003-3148-0337]
dc.identifier.eissn1079-7114
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idSimons Foundation (598399)


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