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dc.contributor.authorErcole, Arien
dc.date.accessioned2020-10-20T23:30:16Z
dc.date.available2020-10-20T23:30:16Z
dc.date.issued2021-01en
dc.identifier.issn0007-0912
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/311725
dc.description.abstractA recent study by Iguchi et al (Anaesth 2020;125(2):192-200) showed that measured renal tissue oxygen tension falls under anaesthesia and may apparently be normalised by increasing arterial oxygen tension. In reality tissue oxygen is a balance between supply, demand and diffusion and is not spatially homogeneous at capillary length scales. This apparent normalisation may be falsely reassuring as such measurements reflect a macroscopic spatial average and being disproportionately influenced by regions of peri-arterial hyperoxia with other areas of tissue remaining unaffected and potentially hypoxic. Therefore, clinicians should not caution before translating the apparently beneficial effects of supraphysiological arterial oxygen levels on measured renal tissue oxygen tension into clinical practice.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier
dc.rightsAll rights reserved
dc.subjectKidneyen
dc.subjectHumansen
dc.subjectOxygenen
dc.subjectAnesthesiaen
dc.subjectPerfusionen
dc.subjectHemodynamicsen
dc.subjectHypoxiaen
dc.titleNormalising renal tissue oxygen tension with higher inspired oxygen concentration may be falsely reassuring. Comment on Br J Anaesth 2020;125:192-200.en
dc.typeArticle
prism.issueIdentifier1en
prism.publicationDate2021en
prism.publicationNameBritish journal of anaesthesiaen
prism.startingPagee32
prism.volume126en
dc.identifier.doi10.17863/CAM.58815
dcterms.dateAccepted2020-10-17en
rioxxterms.versionofrecord10.1016/j.bja.2020.10.017en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-01en
dc.contributor.orcidErcole, Ari [0000-0001-8350-8093]
dc.identifier.eissn1471-6771
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successMon Nov 16 07:30:41 GMT 2020 - Embargo updated*
cam.orpheus.counter5*
rioxxterms.freetoread.startdate2021-11-30


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