Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells.
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Raphel, L., Talasila, A., Cheung, C., & Sinha, S. (2012). Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells.. PloS one, 7 (8), e44052. https://doi.org/10.1371/journal.pone.0044052
Myocardin is thought to have a key role in smooth muscle cell (SMC) development by acting on CArG-dependent genes. However, it is unclear whether myocardin-induced SMC maturation and increases in agonist-induced calcium signalling are also associated with increases in the expression of non-CArG-dependent SMC-specific genes. Moreover, it is unknown whether myocardin promotes SMC development from human embryonic stem cells.
Muscle, Smooth, Vascular, Cells, Cultured, Myocytes, Smooth Muscle, Humans, Myosin Heavy Chains, Trans-Activators, Nuclear Proteins, Cell Differentiation, Muscle Contraction, Phenotype, Embryonic Stem Cells
British Heart Foundation (PG/10/007/28184)
Wellcome Trust (079249/Z/06/H)
External DOI: https://doi.org/10.1371/journal.pone.0044052
This record's URL: https://www.repository.cam.ac.uk/handle/1810/311727
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/