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dc.contributor.authorLjimani, Alexandra
dc.contributor.authorCaroli, Anna
dc.contributor.authorLaustsen, Christoffer
dc.contributor.authorFrancis, Susan
dc.contributor.authorMendichovszky, Iosif Alexandru
dc.contributor.authorBane, Octavia
dc.contributor.authorNery, Fabio
dc.contributor.authorSharma, Kanishka
dc.contributor.authorPohlmann, Andreas
dc.contributor.authorDekkers, Ilona A.
dc.contributor.authorVallee, Jean-Paul
dc.contributor.authorDerlin, Katja
dc.contributor.authorNotohamiprodjo, Mike
dc.contributor.authorLim, Ruth P.
dc.contributor.authorPalmucci, Stefano
dc.contributor.authorSerai, Suraj D.
dc.contributor.authorPeriquito, Joao
dc.contributor.authorWang, Zhen Jane
dc.contributor.authorFroeling, Martijn
dc.contributor.authorThoeny, Harriet C.
dc.contributor.authorPrasad, Pottumarthi
dc.contributor.authorSchneider, Moritz
dc.contributor.authorNiendorf, Thoralf
dc.contributor.authorPullens, Pim
dc.contributor.authorSourbron, Steven
dc.contributor.authorSigmund, Eric E.
dc.date.accessioned2020-10-31T16:08:17Z
dc.date.available2020-10-31T16:08:17Z
dc.date.issued2019-11-01
dc.date.submitted2019-08-06
dc.identifier.citationMagnetic Resonance Materials in Physics, Biology and Medicine, volume 33, issue 1, page 177-195
dc.identifier.issn0968-5243
dc.identifier.others10334-019-00790-y
dc.identifier.other790
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/312308
dc.description.abstractAbstract: Objectives: Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization. Materials and methods: Reported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement. Results: Correlations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65–74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided. Discussion: The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.
dc.languageen
dc.publisherSpringer International Publishing
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectBiomarker
dc.subjectDWI
dc.subjectADC
dc.subjectIVIM
dc.subjectDTI
dc.titleConsensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI
dc.typeArticle
dc.date.updated2020-10-31T16:08:16Z
dc.identifier.doi10.17863/CAM.59402
dcterms.dateAccepted2019-10-19
rioxxterms.versionofrecord10.1007/s10334-019-00790-y
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidLjimani, Alexandra [0000-0002-9748-9927]
dc.contributor.orcidCaroli, Anna [0000-0002-4130-4663]
dc.contributor.orcidFroeling, Martijn [0000-0003-3841-0497]
dc.identifier.eissn1352-8661
pubs.funder-project-idEuropean Cooperation in Science and Technology (CA16103)
pubs.funder-project-idMedical Research Council UK (MR/R02264X/1)
pubs.funder-project-idNational Institute of Diabetes and Digestive and Kidney Diseases (1F32DK109591)
pubs.funder-project-idH2020 European Research Council (115974)
pubs.funder-project-idDeutsche Forschungsgemeinschaft (SFB 1365)
pubs.funder-project-idSwiss Re Foundation (IZCOZ0_177140/1, IZCOZ0_177140/1)
pubs.funder-project-idBundesministerium für Forschung und Technologie (VIP 03P00081)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)