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dc.contributor.authorBaker
dc.contributor.authorTachedjian
dc.contributor.authorBarr
dc.contributor.authorMarsh
dc.contributor.authorTodd
dc.contributor.authorCrameri
dc.contributor.authorCrameri
dc.contributor.authorSmith
dc.contributor.authorHolmes
dc.contributor.authorSuu-Ire
dc.contributor.authorFernandez-Loras
dc.contributor.authorCunningham
dc.contributor.authorWood
dc.contributor.authorWang
dc.date.accessioned2020-11-02T02:07:23Z
dc.date.available2020-11-02T02:07:23Z
dc.date.issued2020-10-30
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/312315
dc.description.abstractBats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic. Here, we describe a new member of the genus Achimota pararubulavirus 3 (AchPV3) and its isolation from the urine of African straw-coloured fruit bats on primary bat kidneys cells. We sequenced and analysed the genome of AchPV3 relative to other Paramyxoviridae, revealing it to be similar to known pararubulaviruses. Phylogenetic analysis of AchPV3 revealed the failure of molecular detection in the urine sample from which AchPV3 was derived and an attachment protein most closely related with AchPV2—a pararubulavirus known to cause cross-species transmission. Together these findings add to the picture of pararubulaviruses, their sources, and variable zoonotic potential, which is key to our understanding of host restriction and spillover of bat-derived paramyxoviruses. AchPV3 represents a novel candidate zoonosis and an important tool for further study.
dc.languageen
dc.publisherMDPI
dc.subjectvirus
dc.subjectzoonosis
dc.subjectbat
dc.subjectpararubulavirus
dc.subjectparamyxovirus
dc.subjectmolecular detection
dc.subjectvirus discovery
dc.subjectelectron microscopy
dc.subjectgenomics
dc.subjectprimary cell lines
dc.titleAchimota Pararubulavirus 3: A New Bat-Derived Paramyxovirus of the Genus Pararubulavirus
dc.typeArticle
dc.date.updated2020-11-02T02:07:22Z
prism.issueIdentifier11
prism.publicationNameViruses
prism.volume12
dc.identifier.doi10.17863/CAM.59409
dcterms.dateAccepted2020-10-27
rioxxterms.versionofrecord10.3390/v12111236
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1999-4915


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