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dc.contributor.authorAlam, Aftab
dc.contributor.authorThelin, Eric P.
dc.contributor.authorTajsic, Tamara
dc.contributor.authorKhan, Danyal Z.
dc.contributor.authorKhellaf, Abdelhakim
dc.contributor.authorPatani, Rickie
dc.contributor.authorHelmy, Adel
dc.date.accessioned2020-11-03T18:31:11Z
dc.date.available2020-11-03T18:31:11Z
dc.date.issued2020-11-03
dc.date.submitted2020-09-10
dc.identifier.others12974-020-02005-x
dc.identifier.other2005
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/312381
dc.description.abstractAbstract: Traumatic brain injury leads to cellular damage which in turn results in the rapid release of damage-associated molecular patterns (DAMPs) that prompt resident cells to release cytokines and chemokines. These in turn rapidly recruit neutrophils, which assist in limiting the spread of injury and removing cellular debris. Microglia continuously survey the CNS (central nervous system) compartment and identify structural abnormalities in neurons contributing to the response. After some days, when neutrophil numbers start to decline, activated microglia and astrocytes assemble at the injury site—segregating injured tissue from healthy tissue and facilitating restorative processes. Monocytes infiltrate the injury site to produce chemokines that recruit astrocytes which successively extend their processes towards monocytes during the recovery phase. In this fashion, monocytes infiltration serves to help repair the injured brain. Neurons and astrocytes also moderate brain inflammation via downregulation of cytotoxic inflammation. Depending on the severity of the brain injury, T and B cells can also be recruited to the brain pathology sites at later time points.
dc.languageen
dc.publisherBioMed Central
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectReview
dc.subjectNeuroinflammation
dc.subjectCellular infiltration
dc.subjectTraumatic brain injury
dc.subjectMicroglial dynamics
dc.titleCellular infiltration in traumatic brain injury
dc.typeArticle
dc.date.updated2020-11-03T18:30:47Z
prism.issueIdentifier1
prism.publicationNameJournal of Neuroinflammation
prism.volume17
dc.identifier.doi10.17863/CAM.59473
dcterms.dateAccepted2020-10-21
rioxxterms.versionofrecord10.1186/s12974-020-02005-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidAlam, Aftab [0000-0001-8089-6721]
dc.identifier.eissn1742-2094
pubs.funder-project-idMedical Research Council (MR/R005036/1)
pubs.funder-project-idNewton Fund (NF170920)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)