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A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity.

Published version
Peer-reviewed

Type

Article

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Authors

Garcia-Carreras, Bernardo 
Hitchings, Matt DT 

Abstract

Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.

Description

Keywords

Antibodies, Viral, Betacoronavirus, COVID-19, Coronavirus Infections, Cross Reactions, Databases, Factual, Humans, Immunization, Passive, Immunoglobulin Isotypes, Middle East Respiratory Syndrome Coronavirus, Pandemics, Pneumonia, Viral, SARS-CoV-2, Seroepidemiologic Studies

Journal Title

Nat Commun

Conference Name

Journal ISSN

2041-1723
2041-1723

Volume Title

11

Publisher

Springer Science and Business Media LLC
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