CACNA1C methylation: association with cortisol, perceived stress, rs1006737 and childhood trauma in males
Reynolds, Gavin P
Future Medicine Ltd
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Pennington, K., Klaus, K., Fachim, H. A., Butler, K., Trischel, K., Dalton, C. F., Heald, A., & et al. (2020). CACNA1C methylation: association with cortisol, perceived stress, rs1006737 and childhood trauma in males. Epigenomics, 0 (0)https://doi.org/10.2217/epi-2020-0034
Aim: We investigated morning cortisol, stress, rs1006737 and childhood trauma relationship with CACNA1C methylation. Materials & methods: Morning cortisol release, childhood trauma and perceived stress were collected and genotyping for rs1006737 conducted in 103 adult males. Genomic DNA extracted from saliva was bisulphite converted and using pyrosequencing methylation determined at 11 CpG sites within intron 3 of CACNA1C. Results: A significant negative correlation between waking cortisol and overall mean methylation was found and a positive correlation between CpG5 methylation and perceived stress. Conclusion: CACNA1C methylation levels may be related to cortisol release and stress perception. Future work should evaluate the influence of altered CACNA1C methylation on stress reactivity to investigate this as a potential mechanism for mental health vulnerability.
Research Article, CACNA1C, childhood trauma, cortisol, DNA methylation, rs1006737, stress
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External DOI: https://doi.org/10.2217/epi-2020-0034
This record's URL: https://www.repository.cam.ac.uk/handle/1810/312713
Embargo: starts 2020-11-10, ends 2021-11-10, duration 12 months from publication.