Show simple item record

dc.contributor.authorZamboni, Elisaen
dc.contributor.authorKemper, Valentin Gen
dc.contributor.authorGoncalves, Nuno Reisen
dc.contributor.authorJia, Keen
dc.contributor.authorKarlaftis, Vasileiosen
dc.contributor.authorBell, Samuel Jen
dc.contributor.authorGiorgio, Josephen
dc.contributor.authorRideaux, Reubenen
dc.contributor.authorGoebel, Raineren
dc.contributor.authorKourtzi, Zoeen
dc.date.accessioned2020-11-11T00:30:44Z
dc.date.available2020-11-11T00:30:44Z
dc.date.issued2020-11-10en
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/312756
dc.description.abstract27 Adapting to the environment statistics by reducing brain responses to repetitive sensory 28 information is key for efficient information processing. Yet, the fine-scale computations that 29 support this adaptive processing in the human brain remain largely unknown. Here, we 30 capitalize on the sub-millimetre resolution of ultra-high field imaging to examine fMRI 31 signals across cortical depth and discern competing hypotheses about the brain mechanisms 32 (feedforward vs. feedback) that mediate adaptive processing. We demonstrate layer-specific 33 suppressive processing within visual cortex, as indicated by stronger BOLD decrease in 34 superficial and middle than deeper layers for gratings that were repeatedly presented at the 35 same orientation. Further, we show altered functional connectivity for adaptation: enhanced 36 feedforward connectivity from V1 to higher visual areas, short-range feedback connectivity 37 between V1 and V2 and long-range feedback occipito-parietal connectivity. Our findings 38 provide evidence for a circuit of local recurrent and feedback interactions that mediate rapid 39 brain plasticity for adaptive information processing.
dc.description.sponsorshipUKRI | Biotechnology and Biological Sciences Research Council (BBSRC): Zoe Kourtzi, H012508; UKRI | Biotechnology and Biological Sciences Research Council (BBSRC): Zoe Kourtzi, BB/P021255/1; Wellcome Trust (WT): Zoe Kourtzi, 205067/Z/16/Z
dc.format.mediumElectronicen
dc.languageengen
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectVisual Cortexen
dc.subjectHumansen
dc.subjectMagnetic Resonance Imagingen
dc.subjectAdaptation, Biologicalen
dc.subjectAdulten
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectYoung Adulten
dc.titleFine-scale computations for adaptive processing in the human brain.en
dc.typeArticle
prism.publicationDate2020en
prism.publicationNameeLifeen
prism.volume9en
dc.identifier.doi10.17863/CAM.59857
dcterms.dateAccepted2020-11-09en
rioxxterms.versionofrecord10.7554/elife.57637en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-11-10en
dc.contributor.orcidZamboni, Elisa [0000-0001-9200-8031]
dc.contributor.orcidKarlaftis, Vasileios [0000-0003-1285-1593]
dc.contributor.orcidRideaux, Reuben [0000-0001-8416-005X]
dc.contributor.orcidGoebel, Rainer [0000-0003-1780-2467]
dc.contributor.orcidKourtzi, Zoe [0000-0001-9441-7832]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (205067/Z/16/Z)
pubs.funder-project-idBBSRC (BB/P021255/1)
datacite.issupplementedby.urlhttps://doi.org/10.17863/CAM.60330
cam.orpheus.counter3*
rioxxterms.freetoread.startdate2023-11-10


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record