On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer.
Published version
Peer-reviewed
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Repository DOI
Type
Article
Change log
Authors
Moser, Tina https://orcid.org/0000-0001-5211-0920
Waldispuehl-Geigl, Julie
Belic, Jelena
Weber, Sabrina
Zhou, Qing
Abstract
We addressed a significant unknown feature of circulating tumor DNA (ctDNA), i.e., how ctDNA levels change during chemotherapy, by serially monitoring ctDNA in patients with colorectal cancer during the 48-h application of FOLFOX. Surprisingly, we did not observe a spike in ctDNA as a sign of a responsive tumor, but instead ctDNA levels initially decreased and remained low in patients with stable disease or partial response. Our observations reveal further insights into cell destruction during chemotherapy with important implications for the management of patients.
Description
Keywords
32 Biomedical and Clinical Sciences, 3211 Oncology and Carcinogenesis, 3204 Immunology, Colo-Rectal Cancer, Cancer, Digestive Diseases, Cancer, 3 Good Health and Well Being
Journal Title
NPJ Precis Oncol
Conference Name
Journal ISSN
2397-768X
2397-768X
2397-768X
Volume Title
4
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) (KLI 764, KLI 710)