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dc.contributor.authorAye, Irvingen
dc.contributor.authorAiken, Catherineen
dc.contributor.authorCharnock-Jones, Stephenen
dc.contributor.authorSmith, Gordonen
dc.date.accessioned2020-11-17T00:30:54Z
dc.date.available2020-11-17T00:30:54Z
dc.date.issued2020-11-13en
dc.identifier.issn0002-9378
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/312960
dc.description.abstractThe placenta is a highly metabolically active organ fulfilling the bioenergetic and biosynthetic needs to support its own rapid growth and that of the fetus. Placental metabolic dysfunction is a common occurrence in preeclampsia although its causal relationship to the pathophysiology is unclear. At the outset, this may simply be seen as an “engine out of fuel”. However, placental metabolism plays a vital role beyond energy production and is linked to physiological and developmental processes. In this review, we discuss the metabolic basis for placental dysfunction and propose that the alterations in energy metabolism may explain many of the placental phenotypes of preeclampsia such as reduced placental and fetal growth, redox imbalance, oxidative stress, altered epigenetic and gene expression profiles, and the functional consequences of these aberrations. We propose that placental metabolic reprogramming reflects the dynamic physiological state allowing the tissue to adapt to developmental changes and respond to preeclampsia stress whereas, the inability to reprogram placental metabolism may result in severe preeclampsia phenotypes. Lastly, we discuss common tested and novel therapeutic strategies for treating placental dysfunction in preeclampsia and their impact on placental energy metabolism as possible explanations into their potential benefits or harm.
dc.description.sponsorshipI.L.M.H. Aye is funded by a Next Generation Fellowship from the Centre for 20 Trophoblast Research, University of Cambridge
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titlePlacental energy metabolism in health and disease-significance of development and implications for preeclampsia.en
dc.typeArticle
prism.publicationDate2020en
prism.publicationNameAmerican journal of obstetrics and gynecologyen
dc.identifier.doi10.17863/CAM.60060
dcterms.dateAccepted2020-11-03en
rioxxterms.versionofrecord10.1016/j.ajog.2020.11.005en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-11-13en
dc.contributor.orcidAye, Irving [0000-0003-3400-5005]
dc.contributor.orcidAiken, Catherine [0000-0002-6510-5626]
dc.contributor.orcidCharnock-Jones, Stephen [0000-0002-2936-4890]
dc.contributor.orcidSmith, Gordon [0000-0003-2124-0997]
dc.identifier.eissn1097-6868
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successTue Nov 17 12:08:37 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2021-11-30


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International