Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes
Authors
Publication Date
2020-11-23Journal Title
Clinical Epigenetics
ISSN
1868-7075
Publisher
BioMed Central
Volume
12
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
F. C. Lopes, A. (2020). Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes. Clinical Epigenetics, 12 (1)https://doi.org/10.1186/s13148-020-00976-5
Abstract
Abstract: Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the nuclear DNA. As such, variations in nuclear gene expression as a consequence of mutations and epigenetic modifications can affect mitochondrial functionality. Conversely, the opposite could also be true. However, the relationship between mitochondrial dysfunction and epigenetics, such as nuclear DNA methylation, remains largely unexplored. Mitochondria function as central metabolic hubs controlling some of the main substrates involved in nuclear DNA methylation, via the one carbon metabolism, the tricarboxylic acid cycle and the methionine pathway. Here, we review key findings and highlight new areas of focus, with the ultimate goal of getting one step closer to understanding the genomic effects of mitochondrial dysfunction on nuclear epigenetic landscapes.
Keywords
Review, Endocrinology and Metabolic Epigenetics, DNA methylation, Nucleus, Mitochondria, Metabolism, DNA, Haplogroups
Identifiers
s13148-020-00976-5, 976
External DOI: https://doi.org/10.1186/s13148-020-00976-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/313223
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/