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dc.contributor.authorF. C. Lopes, Amanda
dc.date.accessioned2020-11-23T16:15:16Z
dc.date.available2020-11-23T16:15:16Z
dc.date.issued2020-11-23
dc.date.submitted2020-09-10
dc.identifier.issn1868-7075
dc.identifier.others13148-020-00976-5
dc.identifier.other976
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/313223
dc.description.abstractAbstract: Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the nuclear DNA. As such, variations in nuclear gene expression as a consequence of mutations and epigenetic modifications can affect mitochondrial functionality. Conversely, the opposite could also be true. However, the relationship between mitochondrial dysfunction and epigenetics, such as nuclear DNA methylation, remains largely unexplored. Mitochondria function as central metabolic hubs controlling some of the main substrates involved in nuclear DNA methylation, via the one carbon metabolism, the tricarboxylic acid cycle and the methionine pathway. Here, we review key findings and highlight new areas of focus, with the ultimate goal of getting one step closer to understanding the genomic effects of mitochondrial dysfunction on nuclear epigenetic landscapes.
dc.languageen
dc.publisherBioMed Central
dc.subjectReview
dc.subjectEndocrinology and Metabolic Epigenetics
dc.subjectDNA methylation
dc.subjectNucleus
dc.subjectMitochondria
dc.subjectMetabolism
dc.subjectDNA
dc.subjectHaplogroups
dc.titleMitochondrial metabolism and DNA methylation: a review of the interaction between two genomes
dc.typeArticle
dc.date.updated2020-11-23T16:15:16Z
prism.issueIdentifier1
prism.publicationNameClinical Epigenetics
prism.volume12
dc.identifier.doi10.17863/CAM.60328
dcterms.dateAccepted2020-11-10
rioxxterms.versionofrecord10.1186/s13148-020-00976-5
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidF. C. Lopes, Amanda [0000-0003-1770-7507]
dc.identifier.eissn1868-7083


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