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dc.contributor.authorPapaioannou, Dimitrios
dc.contributor.authorPetri, Andreas
dc.contributor.authorDovey, Oliver M.
dc.contributor.authorTerreri, Sara
dc.contributor.authorWang, Eric
dc.contributor.authorCollins, Frances A.
dc.contributor.authorWoodward, Lauren A.
dc.contributor.authorWalker, Allison E.
dc.contributor.authorNicolet, Deedra
dc.contributor.authorPepe, Felice
dc.contributor.authorKumchala, Prasanthi
dc.contributor.authorBill, Marius
dc.contributor.authorWalker, Christopher J.
dc.contributor.authorKarunasiri, Malith
dc.contributor.authorMrózek, Krzysztof
dc.contributor.authorGardner, Miranda L.
dc.contributor.authorCamilotto, Virginia
dc.contributor.authorZitzer, Nina
dc.contributor.authorCooper, Jonathan L.
dc.contributor.authorCai, Xiongwei
dc.contributor.authorRong-Mullins, Xiaoqing
dc.contributor.authorKohlschmidt, Jessica
dc.contributor.authorArcher, Kellie J.
dc.contributor.authorFreitas, Michael A.
dc.contributor.authorZheng, Yi
dc.contributor.authorLee, Robert J.
dc.contributor.authorAifantis, Iannis
dc.contributor.authorVassiliou, George
dc.contributor.authorSingh, Guramrit
dc.contributor.authorKauppinen, Sakari
dc.contributor.authorBloomfield, Clara D.
dc.contributor.authorDorrance, Adrienne M.
dc.contributor.authorGarzon, Ramiro
dc.date.accessioned2020-11-24T17:24:20Z
dc.date.available2020-11-24T17:24:20Z
dc.date.issued2019-11-25
dc.date.submitted2018-08-06
dc.identifier.others41467-019-13259-2
dc.identifier.other13259
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/313273
dc.descriptionFunder: U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics)
dc.description.abstractAbstract: Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism, HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/67
dc.subject/631/337
dc.subject/631/337/384
dc.subject/631/337/572
dc.subject/692/4017
dc.subject/14/1
dc.subject/38/22
dc.subject/38/90
dc.subject/38/91
dc.subject/38/89
dc.subject/38/109
dc.subject/42/89
dc.subject/45/15
dc.subject/45/91
dc.subject/45/88
dc.subjectarticle
dc.titleThe long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1 -mutated acute myeloid leukemia
dc.typeArticle
dc.date.updated2020-11-24T17:24:20Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume10
dc.identifier.doi10.17863/CAM.60378
dcterms.dateAccepted2019-10-28
rioxxterms.versionofrecord10.1038/s41467-019-13259-2
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidPetri, Andreas [0000-0002-0425-5794]
dc.contributor.orcidPepe, Felice [0000-0001-6507-9993]
dc.contributor.orcidRong-Mullins, Xiaoqing [0000-0002-2122-552X]
dc.contributor.orcidArcher, Kellie J. [0000-0003-1555-5781]
dc.contributor.orcidVassiliou, George [0000-0003-4337-8022]
dc.contributor.orcidSingh, Guramrit [0000-0002-5283-9540]
dc.contributor.orcidBloomfield, Clara D. [0000-0001-5465-7591]
dc.identifier.eissn2041-1723
pubs.funder-project-idU.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) (CA233338, CA196171, CA180861)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)