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dc.contributor.authorKwon, Young Mi
dc.contributor.authorGori, Kevin
dc.contributor.authorPark, Naomi
dc.contributor.authorPotts, Nicole
dc.contributor.authorSwift, Kate
dc.contributor.authorWang, Jinhong
dc.contributor.authorStammnitz, Maximilian R.
dc.contributor.authorCannell, Naomi
dc.contributor.authorBaez-Ortega, Adrian
dc.contributor.authorComte, Sebastien
dc.contributor.authorFox, Samantha
dc.contributor.authorHarmsen, Colette
dc.contributor.authorHuxtable, Stewart
dc.contributor.authorJones, Menna
dc.contributor.authorKreiss, Alexandre
dc.contributor.authorLawrence, Clare
dc.contributor.authorLazenby, Billie
dc.contributor.authorPeck, Sarah
dc.contributor.authorPye, Ruth
dc.contributor.authorWoods, Gregory
dc.contributor.authorZimmermann, Mona
dc.contributor.authorWedge, David C.
dc.contributor.authorPemberton, David
dc.contributor.authorStratton, Michael R.
dc.contributor.authorHamede, Rodrigo
dc.contributor.authorMurchison, Elizabeth P.
dc.date.accessioned2020-11-25T00:18:32Z
dc.date.available2020-11-25T00:18:32Z
dc.date.issued2020-11-24
dc.date.submitted2020-07-07
dc.identifier.issn1544-9173
dc.identifier.otherpbiology-d-20-02040
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/313274
dc.description.abstractDevil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian devil. The expansion of DFT1 across Tasmania has been documented, but little is known of its evolutionary history. We analysed genomes of 648 DFT1 tumours collected throughout the disease range between 2003 and 2018. DFT1 diverged early into five clades, three spreading widely and two failing to persist. One clade has replaced others at several sites, and rates of DFT1 coinfection are high. DFT1 gradually accumulates copy number variants (CNVs), and its telomere lengths are short but constant. Recurrent CNVs reveal genes under positive selection, sites of genome instability, and repeated loss of a small derived chromosome. Cultured DFT1 cell lines have increased CNV frequency and undergo highly reproducible convergent evolution. Overall, DFT1 is a remarkably stable lineage whose genome illustrates how cancer cells adapt to diverse environments and persist in a parasitic niche.
dc.languageen
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectMedicine and health sciences
dc.subjectBiology and life sciences
dc.subjectComputer and information sciences
dc.titleEvolution and lineage dynamics of a transmissible cancer in Tasmanian devils
dc.typeArticle
dc.date.updated2020-11-25T00:18:32Z
prism.issueIdentifier11
prism.publicationNamePLOS Biology
prism.volume18
dc.identifier.doi10.17863/CAM.60380
dcterms.dateAccepted2020-10-19
rioxxterms.versionofrecord10.1371/journal.pbio.3000926
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: van de Rijn, Matt
dc.contributor.orcidSwift, Kate [0000-0002-1147-7010]
dc.contributor.orcidStammnitz, Maximilian R. [0000-0002-1704-9199]
dc.contributor.orcidFox, Samantha [0000-0002-0371-3458]
dc.contributor.orcidHuxtable, Stewart [0000-0002-4081-053X]
dc.contributor.orcidLazenby, Billie [0000-0003-3328-0670]
dc.contributor.orcidWoods, Gregory [0000-0001-8421-7917]
dc.contributor.orcidZimmermann, Mona [0000-0003-0015-6737]
dc.contributor.orcidWedge, David C. [0000-0002-7572-3196]
dc.contributor.orcidMurchison, Elizabeth P. [0000-0001-7462-8907]
dc.identifier.eissn1545-7885
pubs.funder-project-idWellcome Trust (102942/Z/13/A)
pubs.funder-project-idLeverhulme Trust (Philip Leverhulme Prize)
pubs.funder-project-idNational Science Foundation (US) (DEB-1316549)
pubs.funder-project-idUniversity of Tasmania Foundation (Eric Guiler Tasmanian Devil Research Grants)
pubs.funder-project-idAustralian Research Council (AU) (DE 170101116)
pubs.funder-project-idHerchel Smith Fund (Postgraduate Fellowship)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)