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Adult-Onset ANCA-Associated Vasculitis in SAVI: Extension of the Phenotypic Spectrum, Case Report and Review of the Literature.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Staels, Frederik 
Betrains, Albrecht 
Doubel, Peter 
Willemsen, Mathijs 
Cleemput, Vincent 

Abstract

STING-associated vasculopathy with onset in infancy (SAVI) is an autosomal dominant disorder due to gain-of-function mutations in STING1, also known as TMEM173, encoding for STING. It was reported as a vasculopathy of infancy. However, since its description a wider spectrum of associated manifestations and disease-onset has been observed. We report a kindred with a heterozygous STING mutation (p.V155M) in which the 19-year-old proband suffered from isolated adult-onset ANCA-associated vasculitis. His father suffered from childhood-onset pulmonary fibrosis and renal failure attributed to ANCA-associated vasculitis, and died at the age of 30 years due to respiratory failure. In addition, an overview of the phenotypic spectrum of SAVI is provided highlighting (a) a high phenotypic variability with in some cases isolated manifestations, (b) the potential of adult-onset disease, and (c) a novel manifestation with ANCA-associated vasculitis.

Description

Keywords

SAVI, glomerulonephritis, interferonopathy, primary immunodeficiency, vasculopathy, Age of Onset, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Genetic Predisposition to Disease, Heredity, Heterozygote, Humans, Male, Membrane Proteins, Mutation, Pedigree, Phenotype, Prognosis, Vascular Diseases, Young Adult

Journal Title

Front Immunol

Conference Name

Journal ISSN

1664-3224
1664-3224

Volume Title

11

Publisher

Frontiers Media SA