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dc.contributor.authorWatson, Bridget N. J.
dc.contributor.authorVercoe, Reuben B.
dc.contributor.authorSalmond, George P. C.
dc.contributor.authorWestra, Edze R.
dc.contributor.authorStaals, Raymond H. J
dc.contributor.authorFineran, Peter C.
dc.date.accessioned2020-12-03T16:28:42Z
dc.date.available2020-12-03T16:28:42Z
dc.date.issued2019-12-04
dc.date.submitted2019-09-27
dc.identifier.others41467-019-13445-2
dc.identifier.other13445
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/314459
dc.descriptionFunder: Veni grant, Netherlands Organization for Scientific Research (NWO) [016.Veni.171.047 to RHJS] Health Sciences Career Development Award from the University of Otago, NZ
dc.description.abstractAbstract: Type I CRISPR-Cas systems are abundant and widespread adaptive immune systems in bacteria and can greatly enhance bacterial survival in the face of phage infection. Upon phage infection, some CRISPR-Cas immune responses result in bacterial dormancy or slowed growth, which suggests the outcomes for infected cells may vary between systems. Here we demonstrate that type I CRISPR immunity of Pectobacterium atrosepticum leads to suppression of two unrelated virulent phages, ɸTE and ɸM1. Immunity results in an abortive infection response, where infected cells do not survive, but viral propagation is severely decreased, resulting in population protection due to the reduced phage epidemic. Our findings challenge the view of CRISPR-Cas as a system that protects the individual cell and supports growing evidence of abortive infection by some types of CRISPR-Cas systems.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/326/1321
dc.subject/631/326/4041
dc.subject/631/326/432
dc.subjectarticle
dc.titleType I-F CRISPR-Cas resistance against virulent phages results in abortive infection and provides population-level immunity
dc.typeArticle
dc.date.updated2020-12-03T16:28:42Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume10
dc.identifier.doi10.17863/CAM.61563
dcterms.dateAccepted2019-10-30
rioxxterms.versionofrecord10.1038/s41467-019-13445-2
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWestra, Edze R. [0000-0003-4396-0354]
dc.contributor.orcidStaals, Raymond H. J [0000-0002-5741-9457]
dc.contributor.orcidFineran, Peter C. [0000-0002-4639-6704]
dc.identifier.eissn2041-1723


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)