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dc.contributor.authorPyrillou, Katerina
dc.contributor.authorBurzynski, Laura C
dc.contributor.authorClarke, Murray CH
dc.date.accessioned2020-12-22T00:30:29Z
dc.date.available2020-12-22T00:30:29Z
dc.date.issued2020
dc.identifier.issn1664-3224
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/315354
dc.description.abstractCytokines activate or inhibit immune cell behavior and are thus integral to all immune responses. IL-1α and IL-1β are powerful apical cytokines that instigate multiple downstream processes to affect both innate and adaptive immunity. Multiple studies show that IL-1β is typically activated in macrophages after inflammasome sensing of infection or danger, leading to caspase-1 processing of IL-1β and its release. However, many alternative mechanisms activate IL-1α and IL-1β in atypical cell types, and IL-1 function is also important for homeostatic processes that maintain a physiological state. This review focuses on the less studied, yet arguably more interesting biology of IL-1. We detail the production by, and effects of IL-1 on specific innate and adaptive immune cells, report how IL-1 is required for barrier function at multiple sites, and discuss how perturbation of IL-1 pathways can drive disease. Thus, although IL-1 is primarily studied for driving inflammation after release from macrophages, it is clear that it has a multifaceted role that extends far beyond this, with various unconventional effects of IL-1 vital for health. However, much is still unknown, and a detailed understanding of cell-type and context-dependent actions of IL-1 is required to truly understand this enigmatic cytokine, and safely deploy therapeutics for the betterment of human health.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherFrontiers Media SA
dc.rightsAll rights reserved
dc.subjectMacrophages
dc.subjectAnimals
dc.subjectHumans
dc.subjectInterleukin-1
dc.subjectHomeostasis
dc.subjectImmunity, Innate
dc.subjectAdaptive Immunity
dc.titleAlternative Pathways of IL-1 Activation, and Its Role in Health and Disease.
dc.typeArticle
prism.publicationDate2020
prism.publicationNameFront Immunol
prism.startingPage613170
prism.volume11
dc.identifier.doi10.17863/CAM.62462
dcterms.dateAccepted2020-11-16
rioxxterms.versionofrecord10.3389/fimmu.2020.613170
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-01
dc.contributor.orcidPyrillou, Katerina [0000-0003-0375-7810]
dc.contributor.orcidClarke, Murray [0000-0002-8215-8885]
dc.identifier.eissn1664-3224
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (RG/16/8/32388)
pubs.funder-project-idBritish Heart Foundation (FS/18/19/33371)
pubs.funder-project-idBritish Heart Foundation (FS/20/19/34976)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (FS/18/19/33371)
cam.issuedOnline2020-12-18


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