Show simple item record

dc.contributor.authorBuckland, Matthew S.en
dc.contributor.authorGalloway, James B.en
dc.contributor.authorFhogartaigh, Caoimhe Nicen
dc.contributor.authorMeredith, Lukeen
dc.contributor.authorProvine, Nicholas M.en
dc.contributor.authorBloor, Stuarten
dc.contributor.authorOgbe, Aneen
dc.contributor.authorZelek, Wioleta M.en
dc.contributor.authorSmielewska, Annaen
dc.contributor.authorYakovleva, Annaen
dc.contributor.authorMann, Tiffeneyen
dc.contributor.authorBergamaschi, Lauraen
dc.contributor.authorTurner, Lorindaen
dc.contributor.authorMescia, Fredericaen
dc.contributor.authorToonen, Erik J. M.en
dc.contributor.authorHackstein, Carl-Philippen
dc.contributor.authorAkther, Hossain Delowaren
dc.contributor.authorVieira, Vinicius Adrianoen
dc.contributor.authorCeron-Gutierrez, Lourdesen
dc.contributor.authorPeriselneris, Jimstanen
dc.contributor.authorKiani-Alikhan, Sorenaen
dc.contributor.authorGrigoriadou, Sofiaen
dc.contributor.authorVaghela, Devanen
dc.contributor.authorLear, Sara E.en
dc.contributor.authorTörök, M. Estéeen
dc.contributor.authorHamilton, William L.en
dc.contributor.authorStockton, Joanneen
dc.contributor.authorQuick, Joshen
dc.contributor.authorNelson, Peteren
dc.contributor.authorHunter, Michaelen
dc.contributor.authorCoulter, Tanya I.en
dc.contributor.authorDevlin, Lisaen
dc.contributor.authorBradley, John R.en
dc.contributor.authorSmith, Kenneth G. C.en
dc.contributor.authorOuwehand, Willem H.en
dc.contributor.authorEstcourt, Liseen
dc.contributor.authorHarvala, Helien
dc.contributor.authorRoberts, David J.en
dc.contributor.authorWilkinson, Ian B.en
dc.contributor.authorScreaton, Nicken
dc.contributor.authorLoman, Nicholasen
dc.contributor.authorDoffinger, Raineren
dc.contributor.authorLyons, Paul A.en
dc.contributor.authorMorgan, B. Paulen
dc.contributor.authorGoodfellow, Ian G.en
dc.contributor.authorKlenerman, Paulen
dc.contributor.authorLehner, Paul J.en
dc.contributor.authorMatheson, Nicholas J.en
dc.contributor.authorThaventhiran, James E. D.en
dc.date.accessioned2020-12-22T18:53:32Z
dc.date.available2020-12-22T18:53:32Z
dc.date.issued2020-12-14
dc.date.submitted2020-08-27
dc.identifier.others41467-020-19761-2
dc.identifier.other19761
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/315391
dc.description.abstractAbstract: The response to the coronavirus disease 2019 (COVID-19) pandemic has been hampered by lack of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral therapy. Here we report the use of remdesivir in a patient with COVID-19 and the prototypic genetic antibody deficiency X-linked agammaglobulinaemia (XLA). Despite evidence of complement activation and a robust T cell response, the patient developed persistent SARS-CoV-2 pneumonitis, without progressing to multi-organ involvement. This unusual clinical course is consistent with a contribution of antibodies to both viral clearance and progression to severe disease. In the absence of these confounders, we take an experimental medicine approach to examine the in vivo utility of remdesivir. Over two independent courses of treatment, we observe a temporally correlated clinical and virological response, leading to clinical resolution and viral clearance, with no evidence of acquired drug resistance. We therefore provide evidence for the antiviral efficacy of remdesivir in vivo, and its potential benefit in selected patients.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/326/596/1296
dc.subject/631/326/596/4130
dc.subject/692/699/249/2512
dc.subject/692/699/255/2514
dc.subject/13/31
dc.subject/13/1
dc.subjectarticle
dc.titleTreatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report
dc.typeArticle
dc.date.updated2020-12-22T18:53:32Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume11
dc.identifier.doi10.17863/CAM.62498
dcterms.dateAccepted2020-10-27
rioxxterms.versionofrecord10.1038/s41467-020-19761-2
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBuckland, Matthew S. [0000-0002-5646-4707]
dc.contributor.orcidOgbe, Ane [0000-0001-7774-7215]
dc.contributor.orcidMescia, Frederica [0000-0002-2759-4027]
dc.contributor.orcidToonen, Erik J. M. [0000-0001-9039-635X]
dc.contributor.orcidVieira, Vinicius Adriano [0000-0002-4901-0424]
dc.contributor.orcidKiani-Alikhan, Sorena [0000-0002-1299-4415]
dc.contributor.orcidOuwehand, Willem H. [0000-0002-7744-1790]
dc.contributor.orcidLyons, Paul A. [0000-0001-7035-8997]
dc.contributor.orcidLehner, Paul J. [0000-0001-9383-1054]
dc.contributor.orcidMatheson, Nicholas J. [0000-0002-3318-1851]
dc.contributor.orcidThaventhiran, James E. D. [0000-0001-8616-074X]
dc.identifier.eissn2041-1723


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)