Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study
Authors
Pabst, Alexander
Riedel-Heller, Steffi G.
Jessen, Frank
Turana, Yuda
Handajani, Yvonne S.
Brayne, Carol
Matthews, Fiona E.
Stephan, Blossom C. M.
Lipton, Richard B.
Katz, Mindy J.
Wang, Cuiling
Guerchet, Maëlenn
Preux, Pierre-Marie
Mbelesso, Pascal
Ritchie, Karen
Ancelin, Marie-Laure
Carrière, Isabelle
Guaita, Antonio
Davin, Annalisa
Vaccaro, Roberta
Kim, Ki Woong
Han, Ji Won
Suh, Seung Wan
Shahar, Suzana
Din, Normah C.
Vanoh, Divya
van Boxtel, Martin
Köhler, Sebastian
Ganguli, Mary
Jacobsen, Erin P.
Snitz, Beth E.
Anstey, Kaarin J.
Cherbuin, Nicolas
Kumagai, Shuzo
Chen, Sanmei
Narazaki, Kenji
Ng, Tze Pin
Gao, Qi
Gwee, Xinyi
Brodaty, Henry
Kochan, Nicole A.
Trollor, Julian
Lobo, Antonio
López-Antón, Raúl
Santabárbara, Javier
Crawford, John D.
Lipnicki, Darren M.
Sachdev, Perminder S.
Publication Date
2020-12-18Journal Title
Alzheimer's Research & Therapy
Publisher
BioMed Central
Volume
12
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Röhr, S., Pabst, A., Riedel-Heller, S. G., Jessen, F., Turana, Y., Handajani, Y. S., Brayne, C., et al. (2020). Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimer's Research & Therapy, 12 (1)https://doi.org/10.1186/s13195-020-00734-y
Abstract
Abstract: Background: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods: We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results: The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3–24.4%) and IRT (25.6%, 95%CI = 25.1–26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1–7.0%, to 52.7%, 95%CI = 47.4–58.0%; IRT: 7.8%, 95%CI = 6.8–8.9%, to 52.7%, 95%CI = 47.4–58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions: SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.
Keywords
Research, Subjective cognitive decline, Prevalence, Epidemiology, Individual participant data, Data harmonization, Cohort study
Sponsorship
National Health and Medical Research Council of Australia (1093083)
National Institute on Aging (RF1AG057531)
The Dementia Momentum Fund (PS38235)
European Social Fund (LIFE-103 P1)
Identifiers
s13195-020-00734-y, 734
External DOI: https://doi.org/10.1186/s13195-020-00734-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/315460
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/