The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences
Authors
Pan, Jia-Wern
Zabidi, Muhammad Mamduh Ahmad
Ng, Pei-Sze
Meng, Mei-Yee
Hasan, Siti Norhidayu
Sammut, Stephen-John
Rajadurai, Pathmanathan
Publication Date
2020-12-22Journal Title
Nature Communications
Publisher
Nature Publishing Group UK
Volume
11
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Pan, J., Zabidi, M. M. A., Ng, P., Meng, M., Hasan, S. N., Sandey, B., Sammut, S., et al. (2020). The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences. Nature Communications, 11 (1)https://doi.org/10.1038/s41467-020-20173-5
Abstract
Abstract: Molecular profiling of breast cancer has enabled the development of more robust molecular prognostic signatures and therapeutic options for breast cancer patients. However, non-Caucasian populations remain understudied. Here, we present the mutational, transcriptional, and copy number profiles of 560 Malaysian breast tumours and a comparative analysis of breast cancers arising in Asian and Caucasian women. Compared to breast tumours in Caucasian women, we show an increased prevalence of HER2-enriched molecular subtypes and higher prevalence of TP53 somatic mutations in ER+ Asian breast tumours. We also observe elevated immune scores in Asian breast tumours, suggesting potential clinical response to immune checkpoint inhibitors. Whilst HER2-subtype and enriched immune score are associated with improved survival, presence of TP53 somatic mutations is associated with poorer survival in ER+ tumours. Taken together, these population differences unveil opportunities to improve the understanding of this disease and lay the foundation for precision medicine in different populations.
Keywords
Article, /631/67/1347, /631/67/69, /692/4028/67/1347, /45/23, /45/91, /38/39, /13/51, article
Sponsorship
Newton Fund (MR/P012442/1)
Cancer Research UK (CRUK) (A16942)
Identifiers
s41467-020-20173-5, 20173
External DOI: https://doi.org/10.1038/s41467-020-20173-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/315483
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/