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dc.contributor.authorPan, Jia-Wern
dc.contributor.authorZabidi, Muhammad Mamduh Ahmad
dc.contributor.authorNg, Pei-Sze
dc.contributor.authorMeng, Mei-Yee
dc.contributor.authorHasan, Siti Norhidayu
dc.contributor.authorSandey, Bethan
dc.contributor.authorSammut, Stephen-John
dc.contributor.authorYip, Cheng-Har
dc.contributor.authorRajadurai, Pathmanathan
dc.contributor.authorRueda, Oscar M.
dc.contributor.authorCaldas, Carlos
dc.contributor.authorChin, Suet-Feung
dc.contributor.authorTeo, Soo-Hwang
dc.date.accessioned2020-12-22T19:01:38Z
dc.date.available2020-12-22T19:01:38Z
dc.date.issued2020-12-22
dc.date.submitted2020-04-08
dc.identifier.others41467-020-20173-5
dc.identifier.other20173
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/315483
dc.description.abstractAbstract: Molecular profiling of breast cancer has enabled the development of more robust molecular prognostic signatures and therapeutic options for breast cancer patients. However, non-Caucasian populations remain understudied. Here, we present the mutational, transcriptional, and copy number profiles of 560 Malaysian breast tumours and a comparative analysis of breast cancers arising in Asian and Caucasian women. Compared to breast tumours in Caucasian women, we show an increased prevalence of HER2-enriched molecular subtypes and higher prevalence of TP53 somatic mutations in ER+ Asian breast tumours. We also observe elevated immune scores in Asian breast tumours, suggesting potential clinical response to immune checkpoint inhibitors. Whilst HER2-subtype and enriched immune score are associated with improved survival, presence of TP53 somatic mutations is associated with poorer survival in ER+ tumours. Taken together, these population differences unveil opportunities to improve the understanding of this disease and lay the foundation for precision medicine in different populations.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/631/67/1347
dc.subject/631/67/69
dc.subject/692/4028/67/1347
dc.subject/45/23
dc.subject/45/91
dc.subject/38/39
dc.subject/13/51
dc.subjectarticle
dc.titleThe molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences
dc.typeArticle
dc.date.updated2020-12-22T19:01:37Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume11
dc.identifier.doi10.17863/CAM.62590
dcterms.dateAccepted2020-11-17
rioxxterms.versionofrecord10.1038/s41467-020-20173-5
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSandey, Bethan [0000-0001-9448-8673]
dc.contributor.orcidYip, Cheng-Har [0000-0002-6507-9675]
dc.contributor.orcidRueda, Oscar M. [0000-0003-0008-4884]
dc.contributor.orcidCaldas, Carlos [0000-0003-3547-1489]
dc.contributor.orcidChin, Suet-Feung [0000-0001-5697-1082]
dc.contributor.orcidTeo, Soo-Hwang [0000-0002-0444-590X]
dc.identifier.eissn2041-1723
pubs.funder-project-idNewton Fund (MR/P012442/1)
pubs.funder-project-idCancer Research UK (CRUK) (A16942)


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