Show simple item record

dc.contributor.authorLiu, Xulinen
dc.contributor.authorDounavi, Mariaen
dc.contributor.authorRitchie, Karenen
dc.contributor.authorWells, Katieen
dc.contributor.authorRitchie, Craig Wen
dc.contributor.authorSu, Lien
dc.contributor.authorMuniz-Terrera, Gracielaen
dc.contributor.authorO'Brien, Johnen
dc.date.accessioned2020-12-24T00:30:23Z
dc.date.available2020-12-24T00:30:23Z
dc.date.issued2021-05en
dc.identifier.issn0340-5354
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/315565
dc.description.abstractBackground: Structural brain changes associated with Alzheimer’s disease (AD) can occur decades before the onset of symptoms. The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score has been suggested to be associated with accelerated brain atrophy in middle-aged subjects but the regional specificity of atrophic areas remains to be elucidated. Methods: 3T T1-weighted magnetic resonance imaging scans of 160 cognitively healthy middle-aged participants (mean age = 52) in the PREVENT-Dementia cohort, from baseline and from follow-up after two years, were examined. Images were preprocessed using Computational Anatomy Toolbox 12. Voxel-based morphometry was performed in FSL 6.0.1 to identify areas of grey matter (GM) volume differences both cross-sectionally and longitudinally between subjects with high and low baseline CAIDE score (CAIDE score was dichotomized at cohort-median). A GM percentage of change map was created for each subject for evaluation of atrophy over two years. Analyses were adjusted for age, gender, education and total intracranial volume. Results: Compared to subjects with CAIDE score ≤ 6 (low risk), subjects with CAIDE score > 6 (high risk) showed lower GM volume in the temporal, occipital, and fusiform cortex and lingual gyrus at baseline, and greater percentage of GM loss over two years in the supramarginal gyrus, angular gyrus, precuneus, lateral occipital cortex, superior parietal lobule and cingulate gyrus (corrected P < 0.05). Conclusion: This study demonstrated accelerated GM atrophy concentrated in several AD signature cortical regions in healthy middle-aged subjects with high CAIDE scores.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectBrainen
dc.subjectHumansen
dc.subjectAlzheimer Diseaseen
dc.subjectAtrophyen
dc.subjectMagnetic Resonance Imagingen
dc.subjectLongitudinal Studiesen
dc.subjectMiddle Ageden
dc.titleHigher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.en
dc.typeArticle
prism.endingPage1971
prism.issueIdentifier5en
prism.publicationDate2021en
prism.publicationNameJournal of neurologyen
prism.startingPage1962
prism.volume268en
dc.identifier.doi10.17863/CAM.62671
dcterms.dateAccepted2020-12-19en
rioxxterms.versionofrecord10.1007/s00415-020-10383-8en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-05en
dc.contributor.orcidLiu, Xulin [0000-0002-8219-2848]
dc.contributor.orcidDounavi, Maria [0000-0001-8287-346X]
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.identifier.eissn1432-1459
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successMon Jan 25 12:05:55 GMT 2021 - Embargo updated*
cam.orpheus.counter2*
rioxxterms.freetoread.startdate2022-01-09


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record