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dc.contributor.authorLitviňuková, Monika
dc.contributor.authorTalavera-López, Carlos
dc.contributor.authorMaatz, Henrike
dc.contributor.authorReichart, Daniel
dc.contributor.authorWorth, Catherine L.
dc.contributor.authorLindberg, Eric L.
dc.contributor.authorKanda, Masatoshi
dc.contributor.authorPolanski, Krzysztof
dc.contributor.authorHeinig, Matthias
dc.contributor.authorLee, Michael
dc.contributor.authorNadelmann, Emily R.
dc.contributor.authorRoberts, Kenny
dc.contributor.authorTuck, Liz
dc.contributor.authorFasouli, Eirini S.
dc.contributor.authorDeLaughter, Daniel M.
dc.contributor.authorMcDonough, Barbara
dc.contributor.authorWakimoto, Hiroko
dc.contributor.authorGorham, Joshua M.
dc.contributor.authorSamari, Sara
dc.contributor.authorMahbubani, Krishnaa T.
dc.contributor.authorSaeb-Parsy, Kourosh
dc.contributor.authorPatone, Giannino
dc.contributor.authorBoyle, Joseph J.
dc.contributor.authorZhang, Hongbo
dc.contributor.authorZhang, Hao
dc.contributor.authorViveiros, Anissa
dc.contributor.authorOudit, Gavin Y.
dc.contributor.authorBayraktar, Omer Ali
dc.contributor.authorSeidman, J. G.
dc.contributor.authorSeidman, Christine E.
dc.contributor.authorNoseda, Michela
dc.contributor.authorHubner, Norbert
dc.contributor.authorTeichmann, Sarah A.
dc.date.accessioned2020-12-24T16:10:18Z
dc.date.available2020-12-24T16:10:18Z
dc.date.issued2020-09-24
dc.date.submitted2020-02-10
dc.identifier.issn0028-0836
dc.identifier.others41586-020-2797-4
dc.identifier.other2797
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/315606
dc.description.abstractAbstract: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/208/199
dc.subject/692/308/2056
dc.subject/38/91
dc.subject/45/62
dc.subject/14/32
dc.subject/13
dc.subjectarticle
dc.titleCells of the adult human heart
dc.typeArticle
dc.date.updated2020-12-24T16:10:16Z
prism.endingPage472
prism.issueIdentifier7838
prism.publicationNameNature
prism.startingPage466
prism.volume588
dc.identifier.doi10.17863/CAM.62712
dcterms.dateAccepted2020-09-18
rioxxterms.versionofrecord10.1038/s41586-020-2797-4
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWorth, Catherine L. [0000-0002-1796-9606]
dc.contributor.orcidKanda, Masatoshi [0000-0003-3468-3586]
dc.contributor.orcidPolanski, Krzysztof [0000-0002-2586-9576]
dc.contributor.orcidHeinig, Matthias [0000-0002-5612-1720]
dc.contributor.orcidLee, Michael [0000-0002-0186-4439]
dc.contributor.orcidRoberts, Kenny [0000-0001-6155-0821]
dc.contributor.orcidWakimoto, Hiroko [0000-0003-0225-6424]
dc.contributor.orcidMahbubani, Krishnaa T. [0000-0002-1327-2334]
dc.contributor.orcidSaeb-Parsy, Kourosh [0000-0002-0633-3696]
dc.contributor.orcidPatone, Giannino [0000-0002-7242-0341]
dc.contributor.orcidBoyle, Joseph J. [0000-0002-4337-3320]
dc.contributor.orcidBayraktar, Omer Ali [0000-0001-6055-277X]
dc.contributor.orcidSeidman, Christine E. [0000-0001-6380-1209]
dc.contributor.orcidNoseda, Michela [0000-0002-9553-5029]
dc.contributor.orcidHubner, Norbert [0000-0002-1218-6223]
dc.contributor.orcidTeichmann, Sarah A. [0000-0002-6294-6366]
dc.identifier.eissn1476-4687


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)