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dc.contributor.authorWu, F.
dc.contributor.authorThomas, P. A.
dc.contributor.authorKravets, V. G.
dc.contributor.authorArola, H. O.
dc.contributor.authorSoikkeli, M.
dc.contributor.authorIljin, K.
dc.contributor.authorKim, G.
dc.contributor.authorKim, M.
dc.contributor.authorShin, H. S.
dc.contributor.authorAndreeva, D. V.
dc.contributor.authorNeumann, C.
dc.contributor.authorKüllmer, M.
dc.contributor.authorTurchanin, A.
dc.contributor.authorDe Fazio, D.
dc.contributor.authorBalci, O.
dc.contributor.authorBabenko, V.
dc.contributor.authorLuo, B.
dc.contributor.authorGoykhman, I.
dc.contributor.authorHofmann, S.
dc.contributor.authorFerrari, A. C.
dc.contributor.authorNovoselov, K. S.
dc.contributor.authorGrigorenko, A. N.
dc.date.accessioned2020-12-29T16:17:33Z
dc.date.available2020-12-29T16:17:33Z
dc.date.issued2019-12-30
dc.date.submitted2019-09-08
dc.identifier.others41598-019-56105-7
dc.identifier.other56105
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/315634
dc.description.abstractAbstract: Plasmonic biosensing has emerged as the most sensitive label-free technique to detect various molecular species in solutions and has already proved crucial in drug discovery, food safety and studies of bio-reactions. This technique relies on surface plasmon resonances in ~50 nm metallic films and the possibility to functionalize the surface of the metal in order to achieve selectivity. At the same time, most metals corrode in bio-solutions, which reduces the quality factor and darkness of plasmonic resonances and thus the sensitivity. Furthermore, functionalization itself might have a detrimental effect on the quality of the surface, also reducing sensitivity. Here we demonstrate that the use of graphene and other layered materials for passivation and functionalization broadens the range of metals which can be used for plasmonic biosensing and increases the sensitivity by 3-4 orders of magnitude, as it guarantees stability of a metal in liquid and preserves the plasmonic resonances under biofunctionalization. We use this approach to detect low molecular weight HT-2 toxins (crucial for food safety), achieving phase sensitivity~0.5 fg/mL, three orders of magnitude higher than previously reported. This proves that layered materials provide a new platform for surface plasmon resonance biosensing, paving the way for compact biosensors for point of care testing.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/639/925/918/1054
dc.subject/639/624/1107/510
dc.subject/132/122
dc.subject/128
dc.subject/134
dc.subject/9/10
dc.subjectarticle
dc.titleLayered material platform for surface plasmon resonance biosensing
dc.typeArticle
dc.date.updated2020-12-29T16:17:32Z
prism.issueIdentifier1
prism.publicationNameScientific Reports
prism.volume9
dc.identifier.doi10.17863/CAM.62741
dcterms.dateAccepted2019-12-05
rioxxterms.versionofrecord10.1038/s41598-019-56105-7
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidShin, H. S. [0000-0003-0495-7443]
dc.contributor.orcidDe Fazio, D. [0000-0003-3327-078X]
dc.contributor.orcidBalci, O. [0000-0003-2766-2197]
dc.contributor.orcidBabenko, V. [0000-0001-5372-6487]
dc.contributor.orcidFerrari, A. C. [0000-0003-0907-9993]
dc.contributor.orcidNovoselov, K. S. [0000-0003-4972-5371]
dc.contributor.orcidGrigorenko, A. N. [0000-0002-4109-2672]
dc.identifier.eissn2045-2322


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)