Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance.
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Authors
Yang, Christine
Liu, Yingying
Mellett, Natalie A
Nath, Artika P
de Aguiar Vallim, Thomas Q
Calkin, Anna C
Publication Date
2021-01-04Journal Title
Nat Commun
ISSN
2041-1723
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Bond, S. T., King, E. J., Henstridge, D. C., Tran, A., Moody, S. C., Yang, C., Liu, Y., et al. (2021). Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance.. Nat Commun, 12 (1) https://doi.org/10.1038/s41467-020-20434-3
Abstract
The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (Trim28), a gene proposed to primarily influence adiposity via epigenetic mechanisms in embryonic development. However, in the current study we demonstrate that mice with deletion of Trim28 specifically in committed adipocytes, also develop obesity similar to global Trim28 deletion models, highlighting a post-developmental role for Trim28. These effects were exacerbated in female mice, contributing to the growing notion that Trim28 is a sex-specific regulator of obesity. Mechanistically, this phenotype involves alterations in lipolysis and triglyceride metabolism, explained in part by loss of Klf14 expression, a gene previously demonstrated to modulate adipocyte size and body composition in a sex-specific manner. Thus, these findings provide evidence that Trim28 is a bona fide, sex specific regulator of post-developmental adiposity and WAT function.
Keywords
Article, /631/443/319/1642/393, /692/163/2743, /38/91, /64/60, /13/95, /38/39, /42/41, /49/90, /49/47, article
Sponsorship
Department of Health | National Health and Medical Research Council (NHMRC) (APP1128060)
National Heart Foundation of Australia (Heart Foundation) (101789)
Identifiers
s41467-020-20434-3, 20434
External DOI: https://doi.org/10.1038/s41467-020-20434-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/315660
Rights
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/
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