Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19.
Morris, Andrew Conway
American Society of Hematology
MetadataShow full item record
Zaid, Y., Guessous, F., Puhm, F., Elhamdani, W., Chentoufi, L., Morris, A. C., Cheikh, A., et al. (2021). Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19.. Blood advances, 5 (3), 635-639. https://doi.org/10.1182/bloodadvances.2020003513
In addition to preserving homeostasis and contributing to immunity, platelets may exhibit a dysregulated state in acute respiratory distress syndrome (ARDS), and potentially exacerbate lung injury. Although thrombocytopenia has been associated with increased mortality in ARDS and particularly in H1N1 influenza-infected patients, analysis of quantitative changes in platelet activation levels in ARDS, and how these may differ between the various etiologies of ARDS remains limited.
Blood Platelets, Humans, Serotonin, Thrombin, T-Box Domain Proteins, Platelet Aggregation, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Respiratory Distress Syndrome, COVID-19, SARS-CoV-2
Embargo Lift Date
External DOI: https://doi.org/10.1182/bloodadvances.2020003513
This record's URL: https://www.repository.cam.ac.uk/handle/1810/315854
All rights reserved