Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Zaid, Younes https://orcid.org/0000-0001-8750-9106
Guessous, Fadila
Puhm, Florian
Elhamdani, Wail
Chentoufi, Lamyae
Abstract
In addition to preserving homeostasis and contributing to immunity, platelets may exhibit a dysregulated state in acute respiratory distress syndrome (ARDS), and potentially exacerbate lung injury. Although thrombocytopenia has been associated with increased mortality in ARDS and particularly in H1N1 influenza-infected patients, analysis of quantitative changes in platelet activation levels in ARDS, and how these may differ between the various etiologies of ARDS remains limited.
Description
Keywords
Adult, Aged, Aged, 80 and over, Blood Platelets, COVID-19, Female, Humans, Male, Middle Aged, Platelet Aggregation, Respiratory Distress Syndrome, SARS-CoV-2, Serotonin, T-Box Domain Proteins, Thrombin
Journal Title
Blood Adv
Conference Name
Journal ISSN
2473-9529
2473-9537
2473-9537
Volume Title
5
Publisher
American Society of Hematology
Publisher DOI
Rights
All rights reserved
Sponsorship
none