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dc.contributor.authorTambur, Anat R
dc.contributor.authorCampbell, Patricia
dc.contributor.authorChong, Anita S
dc.contributor.authorFeng, Sandy
dc.contributor.authorFord, Mandy L
dc.contributor.authorGebel, Howard
dc.contributor.authorGill, Ronald G
dc.contributor.authorKelsoe, Garnett
dc.contributor.authorKosmoliaptsis, Vasilis
dc.contributor.authorMannon, Roslyn B
dc.contributor.authorMengel, Michael
dc.contributor.authorReed, Elaine F
dc.contributor.authorValenzuela, Nicole M
dc.contributor.authorWiebe, Chris
dc.contributor.authorDijke, I Esme
dc.contributor.authorSullivan, Harold C
dc.contributor.authorNickerson, Peter
dc.date.accessioned2021-01-08T00:31:30Z
dc.date.available2021-01-08T00:31:30Z
dc.date.issued2020-10
dc.identifier.issn1600-6135
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/315882
dc.description.abstractThe purpose of the STAR 2019 Working Group was to build on findings from the initial STAR report to further clarify the expectations, limitations, perceptions, and utility of alloimmune assays that are currently in use or in development for risk assessment in the setting of organ transplantation. The goal was to determine the precision and clinical feasibility/utility of such assays in evaluating both memory and primary alloimmune risks. The process included a critical review of biologically driven, state-of-the-art, clinical diagnostics literature by experts in the field and an open public forum in a face-to-face meeting to promote broader engagement of the American Society of Transplantation and American Society of Histocompatibility and Immunogenetics membership. This report summarizes the literature review and the workshop discussions. Specifically, it highlights (1) available assays to evaluate the attributes of HLA antibodies and their utility both as clinical diagnostics and as research tools to evaluate the effector mechanisms driving rejection; (2) potential assays to assess the presence of alloimmune T and B cell memory; and (3) progress in the development of HLA molecular mismatch computational scores as a potential prognostic biomarker for primary alloimmunity and its application in research trial design.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectIsoantibodies
dc.subjectHLA Antigens
dc.subjectKidney Transplantation
dc.subjectGroup Processes
dc.subjectHistocompatibility
dc.subjectGraft Rejection
dc.titleSensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report.
dc.typeArticle
prism.endingPage2668
prism.issueIdentifier10
prism.publicationDate2020
prism.publicationNameAm J Transplant
prism.startingPage2652
prism.volume20
dc.identifier.doi10.17863/CAM.62993
dcterms.dateAccepted2020-04-20
rioxxterms.versionofrecord10.1111/ajt.15937
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-10
dc.contributor.orcidTambur, Anat R [0000-0002-0320-9825]
dc.contributor.orcidCampbell, Patricia [0000-0002-1909-4807]
dc.contributor.orcidChong, Anita S [0000-0003-0460-0196]
dc.contributor.orcidFord, Mandy L [0000-0001-6736-4421]
dc.contributor.orcidMannon, Roslyn B [0000-0003-1776-3680]
dc.contributor.orcidMengel, Michael [0000-0002-7222-3356]
dc.contributor.orcidReed, Elaine F [0000-0002-3524-545X]
dc.contributor.orcidValenzuela, Nicole M [0000-0003-2024-5382]
dc.contributor.orcidWiebe, Chris [0000-0002-1006-3545]
dc.contributor.orcidNickerson, Peter [0000-0002-7393-7799]
dc.identifier.eissn1600-6143
rioxxterms.typeJournal Article/Review
cam.issuedOnline2020-05-27


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International