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dc.contributor.authorCassidy, Liam D.
dc.contributor.authorYoung, Andrew R. J.
dc.contributor.authorYoung, Christopher N. J.
dc.contributor.authorSoilleux, Elizabeth J.
dc.contributor.authorFielder, Edward
dc.contributor.authorWeigand, Bettina M.
dc.contributor.authorLagnado, Anthony
dc.contributor.authorBrais, Rebecca
dc.contributor.authorKtistakis, Nicholas T.
dc.contributor.authorWiggins, Kimberley A.
dc.contributor.authorPyrillou, Katerina
dc.contributor.authorClarke, Murray C. H.
dc.contributor.authorJurk, Diana
dc.contributor.authorPassos, Joao F.
dc.contributor.authorNarita, Masashi
dc.date.accessioned2021-01-15T16:15:09Z
dc.date.available2021-01-15T16:15:09Z
dc.date.issued2020-01-16
dc.date.submitted2019-01-17
dc.identifier.others41467-019-14187-x
dc.identifier.other14187
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316240
dc.description.abstractAbstract: Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to ageing. A decrease in autophagy is associated with increasing age, yet it is unknown if this is causal in the ageing process, and whether autophagy restoration can counteract these ageing effects. Here we demonstrate that systemic autophagy inhibition induces the premature acquisition of age-associated phenotypes and pathologies in mammals. Remarkably, autophagy restoration provides a near complete recovery of morbidity and a significant extension of lifespan; however, at the molecular level this rescue appears incomplete. Importantly autophagy-restored mice still succumb earlier due to an increase in spontaneous tumour formation. Thus, our data suggest that chronic autophagy inhibition confers an irreversible increase in cancer risk and uncovers a biphasic role of autophagy in cancer development being both tumour suppressive and oncogenic, sequentially.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/67
dc.subject/631/80/39/2346
dc.subject/692/308/1426
dc.subject/13/51
dc.subject/13/21
dc.subject/13/89
dc.subject/64/60
dc.subjectarticle
dc.titleTemporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
dc.typeArticle
dc.date.updated2021-01-15T16:15:08Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume11
dc.identifier.doi10.17863/CAM.63349
dcterms.dateAccepted2019-12-19
rioxxterms.versionofrecord10.1038/s41467-019-14187-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidCassidy, Liam D. [0000-0002-9312-6256]
dc.contributor.orcidYoung, Christopher N. J. [0000-0001-7512-8971]
dc.contributor.orcidPyrillou, Katerina [0000-0003-0375-7810]
dc.contributor.orcidJurk, Diana [0000-0003-4486-0857]
dc.contributor.orcidNarita, Masashi [0000-0001-7764-577X]
dc.identifier.eissn2041-1723


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)