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dc.contributor.authorSmith, Matthew E.
dc.contributor.authorWeir, Anna E.
dc.contributor.authorPrior, Daisy C.C.
dc.contributor.authorCope, Wei
dc.contributor.authorTysome, James R.
dc.contributor.authorSutcliffe, Michael
dc.date.accessioned2021-01-16T16:06:42Z
dc.date.available2021-01-16T16:06:42Z
dc.date.issued2020-01-17
dc.date.submitted2019-08-02
dc.identifier.issn0140-0118
dc.identifier.others11517-020-02121-z
dc.identifier.other2121
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316318
dc.description.abstractAbstract: Obstructive Eustachian tube dysfunction (OETD) is a common condition resulting from inadequate opening of the Eustachian tube (ET). A new surgical treatment involves high-pressure inflation of a balloon within the ET, with the aim of dilating the soft tissue structure. However, the mechanical effects of this intervention have not been established, nor the impact of changing device size or other technical parameters. A novel experimental technique allowed quantification of plastic and elastic tissue deformation in model materials and then human cadaver ETs during balloon dilation, based on the measured balloon inflation pressure-volume relationship. Plastic tissue deformation was found to be greater using larger balloons and deeper device insertion, but increasing the inflation pressure had a more limited effect, with most deformation occurring well below the clinically used pressures. Histological assessment of ET tissue suggested that mucosal tearing and cartilage cracking were in part responsible for the mechanical changes. Balloon dilation of the ET has huge potential if found to be clinically effective, but currently there is a need to understand and develop the technique further. The novel methods employed in this study will be valuable in future laboratory and in vivo studies of ET balloon dilation. Pressures are reported in Bar as this unit is used for medical balloon dilation procedures in clinical practice. 1 Bar = 100,000 Pa. Graphical abstract captionDilation of the Eustachian tube for obstructive dysfunction is performed clinically with 3- and 6-mm-diameter balloons of approximately the same overall length. Our data suggest that dilation with a 6-mm balloon causes greater deformation of the soft tissue structure than dilation with a 3-mm balloon. This difference has yet to be demonstrated clinically. Plastic deformation was measured in terms of energy (J) dissipated during balloon inflation.
dc.languageen
dc.publisherSpringer Berlin Heidelberg
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectOriginal Article
dc.subjectEustachian tube
dc.subjectDilation
dc.subjectBalloon
dc.subjectPressure
dc.subjectDeformation
dc.subjectMechanics
dc.subjectHistology
dc.titleThe mechanism of balloon Eustachian tuboplasty: a biomechanical study
dc.typeArticle
dc.date.updated2021-01-16T16:06:42Z
prism.endingPage699
prism.issueIdentifier4
prism.publicationNameMedical & Biological Engineering & Computing
prism.startingPage689
prism.volume58
dc.identifier.doi10.17863/CAM.63427
dcterms.dateAccepted2020-01-03
rioxxterms.versionofrecord10.1007/s11517-020-02121-z
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSmith, Matthew E. [0000-0001-8147-1549]
dc.identifier.eissn1741-0444
pubs.funder-project-idCambridge Hearing Trust (NA)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)