The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor
Authors
Garay, Samantha M.
Mueller, Annett
Sumption, Lorna A.
Ghevaert, Cedric
Publication Date
2021-01-18Journal Title
Translational Psychiatry
Publisher
Nature Publishing Group UK
Volume
11
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Dingsdale, H., Nan, X., Garay, S. M., Mueller, A., Sumption, L. A., Chacón-Fernández, P., Martinez-Garay, I., et al. (2021). The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor. Translational Psychiatry, 11 (1) https://doi.org/10.1038/s41398-020-01176-8
Description
Funder: European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement 663830
Funder: Welsh Government’s Sêr Cymru programme
Funder: NHS Blood and Transplant
Abstract
Abstract: Brain-derived neurotrophic factor (BDNF) plays crucial roles in brain function. Numerous studies report alterations in BDNF levels in human serum in various neurological conditions, including mood disorders such as depression. However, little is known about BDNF levels in the blood during pregnancy. We asked whether maternal depression and/or anxiety during pregnancy were associated with altered serum BDNF levels in mothers (n = 251) and their new-born infants (n = 212). As prenatal exposure to maternal mood disorders significantly increases the risk of neurological conditions in later life, we also examined the possibility of placental BDNF transfer by developing a new mouse model. We found no association between maternal symptoms of depression and either maternal or infant cord blood serum BDNF. However, maternal symptoms of anxiety correlated with significantly raised maternal serum BDNF exclusively in mothers of boys (r = 0.281; P = 0.005; n = 99). Serum BDNF was significantly lower in male infants than female infants but neither correlated with maternal anxiety symptoms. Consistent with this observation, we found no evidence for BDNF transfer across the placenta. We conclude that the placenta protects the developing fetus from maternal changes in serum BDNF that could otherwise have adverse consequences for fetal development.
Keywords
Article, /692/699/476/1414, /631/477, /64/60, /82/80, /38/1, /38, /64, article
Sponsorship
RCUK | Medical Research Council (MRC) (MR/N013794/1)
Deutsche Forschungsgemeinschaft (German Research Foundation) (MU 4099/1-1)
RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) (BB/S002359/1)
Identifiers
s41398-020-01176-8, 1176
External DOI: https://doi.org/10.1038/s41398-020-01176-8
This record's URL: https://www.repository.cam.ac.uk/handle/1810/316342
Rights
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/
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