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dc.contributor.authorDingsdale, Hayley
dc.contributor.authorNan, Xinsheng
dc.contributor.authorGaray, Samantha M.
dc.contributor.authorMueller, Annett
dc.contributor.authorSumption, Lorna A.
dc.contributor.authorChacón-Fernández, Pedro
dc.contributor.authorMartinez-Garay, Isabel
dc.contributor.authorGhevaert, Cedric
dc.contributor.authorBarde, Yves-Alain
dc.contributor.authorJohn, Rosalind M.
dc.date.accessioned2021-01-18T16:14:08Z
dc.date.available2021-01-18T16:14:08Z
dc.date.issued2021-01-18
dc.date.submitted2020-06-09
dc.identifier.others41398-020-01176-8
dc.identifier.other1176
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316342
dc.descriptionFunder: European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement 663830
dc.descriptionFunder: Welsh Government’s Sêr Cymru programme
dc.descriptionFunder: NHS Blood and Transplant
dc.description.abstractAbstract: Brain-derived neurotrophic factor (BDNF) plays crucial roles in brain function. Numerous studies report alterations in BDNF levels in human serum in various neurological conditions, including mood disorders such as depression. However, little is known about BDNF levels in the blood during pregnancy. We asked whether maternal depression and/or anxiety during pregnancy were associated with altered serum BDNF levels in mothers (n = 251) and their new-born infants (n = 212). As prenatal exposure to maternal mood disorders significantly increases the risk of neurological conditions in later life, we also examined the possibility of placental BDNF transfer by developing a new mouse model. We found no association between maternal symptoms of depression and either maternal or infant cord blood serum BDNF. However, maternal symptoms of anxiety correlated with significantly raised maternal serum BDNF exclusively in mothers of boys (r = 0.281; P = 0.005; n = 99). Serum BDNF was significantly lower in male infants than female infants but neither correlated with maternal anxiety symptoms. Consistent with this observation, we found no evidence for BDNF transfer across the placenta. We conclude that the placenta protects the developing fetus from maternal changes in serum BDNF that could otherwise have adverse consequences for fetal development.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/692/699/476/1414
dc.subject/631/477
dc.subject/64/60
dc.subject/82/80
dc.subject/38/1
dc.subject/38
dc.subject/64
dc.subjectarticle
dc.titleThe placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor
dc.typeArticle
dc.date.updated2021-01-18T16:14:08Z
prism.issueIdentifier1
prism.publicationNameTranslational Psychiatry
prism.volume11
dc.identifier.doi10.17863/CAM.63452
dcterms.dateAccepted2020-11-30
rioxxterms.versionofrecord10.1038/s41398-020-01176-8
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidDingsdale, Hayley [0000-0002-2919-8722]
dc.contributor.orcidNan, Xinsheng [0000-0002-0865-7934]
dc.contributor.orcidChacón-Fernández, Pedro [0000-0003-0925-814X]
dc.contributor.orcidMartinez-Garay, Isabel [0000-0001-6849-7496]
dc.contributor.orcidBarde, Yves-Alain [0000-0002-7627-461X]
dc.contributor.orcidJohn, Rosalind M. [0000-0002-3827-7617]
dc.identifier.eissn2158-3188
pubs.funder-project-idRCUK | Medical Research Council (MRC) (MR/N013794/1)
pubs.funder-project-idDeutsche Forschungsgemeinschaft (German Research Foundation) (MU 4099/1-1)
pubs.funder-project-idRCUK | Biotechnology and Biological Sciences Research Council (BBSRC) (BB/S002359/1)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)