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dc.contributor.authorLiang, Shikang
dc.contributor.authorChaplin, Amanda K
dc.contributor.authorStavridi, Antonia Kefala
dc.contributor.authorAppleby, Robert
dc.contributor.authorHnizda, Ales
dc.contributor.authorBlundell, Tom L
dc.date.accessioned2021-01-20T09:51:07Z
dc.date.available2021-01-20T09:51:07Z
dc.date.issued2021-08
dc.identifier.issn0079-6107
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316479
dc.description.abstractNon-homologous end joining (NHEJ) is the preferred pathway for the repair of DNA double-strand breaks in humans. Here we describe three structural aspects of the repair pathway: stages, scaffolds and strings. We discuss the orchestration of DNA repair to guarantee robust and efficient NHEJ. We focus on structural studies over the past two decades, not only using X-ray diffraction, but also increasingly exploiting cryo-EM to investigate the macromolecular assemblies.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.rightsAll rights reserved
dc.titleStages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM.
dc.typeArticle
prism.endingPage73
prism.publicationDate2021
prism.publicationNameProg Biophys Mol Biol
prism.startingPage60
prism.volume163
dc.identifier.doi10.17863/CAM.63586
dcterms.dateAccepted2020-11-26
rioxxterms.versionofrecord10.1016/j.pbiomolbio.2020.11.008
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-08
dc.contributor.orcidLiang, Shikang [0000-0002-6930-7882]
dc.contributor.orcidBlundell, Tom [0000-0002-2708-8992]
dc.identifier.eissn1873-1732
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (093167/Z/10/Z)
pubs.funder-project-idWellcome Trust (200814/Z/16/Z)
cam.issuedOnline2020-12-04
cam.orpheus.successMon Jan 25 12:05:23 GMT 2021 - Embargo updated
rioxxterms.freetoread.startdate2021-12-04


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