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dc.contributor.authorWillis, Cory M.
dc.contributor.authorNicaise, Alexandra M.
dc.contributor.authorBongarzone, Ernesto R.
dc.contributor.authorGivogri, Maria
dc.contributor.authorReiter, Cory R.
dc.contributor.authorHeintz, Olivia
dc.contributor.authorJellison, Evan R.
dc.contributor.authorSutter, Pearl A.
dc.contributor.authorTeHennepe, Gregg
dc.contributor.authorAnanda, Guruprasad
dc.contributor.authorVella, Anthony T.
dc.contributor.authorCrocker, Stephen J.
dc.date.accessioned2021-01-20T16:20:22Z
dc.date.available2021-01-20T16:20:22Z
dc.date.issued2020-01-21
dc.date.submitted2019-04-30
dc.identifier.others41598-020-57663-x
dc.identifier.other57663
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316514
dc.description.abstractAbstract: The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with astrocyte hypertrophy and aging has been implicated as a basis for these pathological changes. Aging tissues accumulate chronic cellular stress, which can lead to the development of a pro-inflammatory phenotype that can be associated with cellular senescence. Herein, we provide evidence that astrocytes aged in culture develop a spontaneous pro-inflammatory and senescence-like phenotype. We found that extracellular vesicles (EVs) from young astrocyte were sufficient to convey support for oligodendrocyte differentiation while this support was lost by EVs from aged astrocytes. Importantly, the negative influence of culture age on astrocytes, and their cognate EVs, could be countered by treatment with rapamycin. Comparative proteomic analysis of EVs from young and aged astrocytes revealed peptide repertoires unique to each age. Taken together, these findings provide new information on the contribution of EVs as potent mediators by which astrocytes can extert changing influence in either the disease or aged brain.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/378
dc.subject/631/378/2596
dc.subject/631/378/2596/1308
dc.subject/13/31
dc.subject/14/28
dc.subject/64/60
dc.subject/82/81
dc.subject/82/80
dc.subject/96/1
dc.subject/14/63
dc.subject/82/29
dc.subject/96/106
dc.subjectarticle
dc.titleAstrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age
dc.typeArticle
dc.date.updated2021-01-20T16:20:21Z
prism.issueIdentifier1
prism.publicationNameScientific Reports
prism.volume10
dc.identifier.doi10.17863/CAM.63622
dcterms.dateAccepted2020-01-06
rioxxterms.versionofrecord10.1038/s41598-020-57663-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidNicaise, Alexandra M. [0000-0001-7160-5988]
dc.contributor.orcidCrocker, Stephen J. [0000-0003-4529-1385]
dc.identifier.eissn2045-2322
pubs.funder-project-idDr. Ralph and Marian Falk Medical Research Trust (Falk Medical Research Trust) (0-0000)
pubs.funder-project-idU.S. Department of Health & Human Services | National Institutes of Health (NIH) (NS087578)
pubs.funder-project-idNational Multiple Sclerosis Society (National MS Society) (RG-1802-30211)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)