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dc.contributor.authorBrown, Stephanie S. G.
dc.contributor.authorMak, Elijah
dc.contributor.authorZaman, Shahid
dc.date.accessioned2021-01-21T05:09:58Z
dc.date.available2021-01-21T05:09:58Z
dc.date.issued2021-01-07
dc.date.submitted2020-11-14
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316535
dc.description.abstractIn recent decades, the field of neuroimaging has experienced a surge of popularity and innovation which has led to significant advancements in the understanding of neurological disease, if not immediate clinical translation. In the case of Down's syndrome, a complex interplay of neurodevelopmental and neurodegenerative processes occur as a result of the trisomy of chromosome 21. The substantial potential impact of improved clinical intervention and the limited research under-taken to date make it a prime candidate for longitudinal neuroimaging-based study. However, as with a multitude of other multifaceted brain-based disorders, singular utilization of lone modality imaging has limited interpretability and applicability. Indeed, a present challenge facing the neuroimaging community as a whole is the methodological integration of multi-modal imaging to enhance clinical understanding. This review therefore aims to assess the current literature in Down's syndrome utilizing a multi-modal approach with regards to improvement upon consideration of a single modality. Additionally, we discuss potential avenues of future research that may effectively combine structural, functional and molecular-based imaging techniques for the significant benefit of the understanding of Down's syndrome pathology.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectNeurology
dc.subjectDown's syndrome (DS)
dc.subjectAlzheimer's disease
dc.subjectmulti-modal
dc.subjectMRI
dc.subjectPET
dc.subjectneuroimaging
dc.titleMulti-Modal Imaging in Down's Syndrome: Maximizing Utility Through Innovative Neuroimaging Approaches
dc.typeArticle
dc.date.updated2021-01-21T05:09:58Z
prism.publicationNameFrontiers in Neurology
prism.volume11
dc.identifier.doi10.17863/CAM.63643
dcterms.dateAccepted2020-12-08
rioxxterms.versionofrecord10.3389/fneur.2020.629463
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1664-2295


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)