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dc.contributor.authorFerreira Castro, André
dc.contributor.authorBaltruschat, Lothar
dc.contributor.authorStürner, Tomke
dc.contributor.authorBahrami, Amirhoushang
dc.contributor.authorJedlicka, Peter
dc.contributor.authorTavosanis, Gaia
dc.contributor.authorCuntz, Hermann
dc.date.accessioned2021-01-27T05:02:42Z
dc.date.available2021-01-27T05:02:42Z
dc.date.issued2020-11-26
dc.date.submitted2020-07-09
dc.identifier.other60920
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316760
dc.description.abstractClass I ventral posterior dendritic arborisation (c1vpda) proprioceptive sensory neurons respond to contractions in the Drosophila larval body wall during crawling. Their dendritic branches run along the direction of contraction, possibly a functional requirement to maximise membrane curvature during crawling contractions. Although the molecular machinery of dendritic patterning in c1vpda has been extensively studied, the process leading to the precise elaboration of their comb-like shapes remains elusive. Here, to link dendrite shape with its proprioceptive role, we performed long-term, non-invasive, in vivo time-lapse imaging of c1vpda embryonic and larval morphogenesis to reveal a sequence of differentiation stages. We combined computer models and dendritic branch dynamics tracking to propose that distinct sequential phases of stochastic growth and retraction achieve efficient dendritic trees both in terms of wire and function. Our study shows how dendrite growth balances structure–function requirements, shedding new light on general principles of self-organisation in functionally specialised dendrites.
dc.languageen
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectDevelopmental Biology
dc.subjectNeuroscience
dc.subjectdendrite function
dc.subjectdendrite growth
dc.subjectdendrite retraction
dc.subjectmechanotransduction
dc.subjectself-organisation
dc.subjectcomputer model
dc.subjectD. melanogaster
dc.titleAchieving functional neuronal dendrite structure through sequential stochastic growth and retraction
dc.typeArticle
dc.date.updated2021-01-27T05:02:41Z
prism.publicationNameeLife
prism.volume9
dc.identifier.doi10.17863/CAM.63874
dcterms.dateAccepted2020-11-15
rioxxterms.versionofrecord10.7554/elife.60920
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: O'Leary, Timothy
datacite.contributor.supervisorsenior_editor: VijayRaghavan, K
dc.contributor.orcidFerreira Castro, André [0000-0002-6841-1952]
dc.contributor.orcidStürner, Tomke [0000-0003-4054-0784]
dc.contributor.orcidBahrami, Amirhoushang [0000-0001-5841-2516]
dc.contributor.orcidJedlicka, Peter [0000-0001-6571-5742]
dc.contributor.orcidTavosanis, Gaia [0000-0002-8679-5515]
dc.contributor.orcidCuntz, Hermann [0000-0001-5445-0507]
dc.identifier.eissn2050-084X
pubs.funder-project-idBundesministerium für Bildung und Forschung (01GQ1406)
pubs.funder-project-idDeutsche Forschungsgemeinschaft (SPP 1464)
pubs.funder-project-idUniversity Medical Center Giessen and Marburg (UKGM) (Core Funding)
pubs.funder-project-idDeutsches Zentrum für Neurodegenerative Erkrankungen (Core Funding)
pubs.funder-project-idBundesministerium für Bildung und Forschung (031L0229)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)