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dc.contributor.authorErlendsson, Simon
dc.contributor.authorTeilum, Kaare
dc.date.accessioned2021-01-28T08:02:02Z
dc.date.available2021-01-28T08:02:02Z
dc.date.issued2021-01-14
dc.date.submitted2020-10-09
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/316806
dc.description.abstractWhen characterizing biomolecular interactions, avidity, is an umbrella term used to describe the accumulated strength of multiple specific and unspecific interactions between two or more interaction partners. In contrast to the affinity, which is often sufficient to describe monovalent interactions in solution and where the binding strength can be accurately determined by considering only the relationship between the microscopic association and dissociation rates, the avidity is a phenomenological macroscopic parameter linked to several microscopic events. Avidity also covers potential effects of reduced dimensionality and/or hindered diffusion observed at or near surfaces e.g., at the cell membrane. Avidity is often used to describe the discrepancy or the “extra on top” when cellular interactions display binding that are several orders of magnitude stronger than those estimated in vitro. Here we review the principles and theoretical frameworks governing avidity in biological systems and the methods for predicting and simulating avidity. While the avidity and effects thereof are well-understood for extracellular biomolecular interactions, we present here examples of, and discuss how, avidity and the underlying kinetics influences intracellular signaling processes.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMolecular Biosciences
dc.subjectavidity
dc.subjectfunctional affinity
dc.subjectretention time
dc.subjectcellular avidity
dc.subjectmodeling avidity
dc.titleBinding Revisited—Avidity in Cellular Function and Signaling
dc.typeArticle
dc.date.updated2021-01-28T08:02:01Z
prism.publicationNameFrontiers in Molecular Biosciences
prism.volume7
dc.identifier.doi10.17863/CAM.63921
dcterms.dateAccepted2020-12-09
rioxxterms.versionofrecord10.3389/fmolb.2020.615565
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2296-889X


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)